Inoue T, Inoue T, Chatani M, Teshima T
Department of Radiation Therapy, Center for Adult Diseases, Osaka, Japan.
Strahlenther Onkol. 1992 Jan;168(1):23-6.
From May 1982 through December 1986, 116 T1 glottic carcinomas were treated with radiotherapy in a prospective randomized study to determine the effect of radiation field size. Patients were treated with a total dose of 60 Gy over six weeks using 4 MV X-ray, wedge filter and shell. Local control rates treated with a field size of 5 x 5 cm2 and 6 x 6 cm2 were 93% and 95%, respectively. Persistent laryngeal edema occurred in 4% of cases treated with 5 x 5 cm2 and 21% with 6 x 6 cm2 (p less than 0.02). The rate of late laryngeal edema was dependent upon the treatment volume. A larger treatment field yielded a higher minor complication rate without improvement of local control rate.
从1982年5月至1986年12月，在一项前瞻性随机研究中，对116例T1期声门癌患者进行了放射治疗，以确定照射野大小的影响。患者使用4兆伏X射线、楔形滤过器和铅挡块，在六周内接受了总量为60戈瑞的治疗。照射野大小为5×5平方厘米和6×6平方厘米的局部控制率分别为93%和95%。5×5平方厘米照射野治疗的病例中4%出现持续性喉水肿，6×6平方厘米照射野治疗的病例中21%出现持续性喉水肿（p小于0.02）。晚期喉水肿发生率取决于治疗体积。较大的治疗野产生了更高的轻微并发症发生率，而局部控制率并未提高。
