喉癌与喉咽反流病
Laryngeal carcinoma and laryngo-pharyngeal reflux disease.
作者信息
Galli J, Cammarota G, Volante M, De Corso E, Almadori G, Paludetti G
机构信息
ENT Department, "A. Gemelli" Polyclinic, Catholic University, Rome, Italy.
出版信息
Acta Otorhinolaryngol Ital. 2006 Oct;26(5):260-3.
Abstract
A correlation between laryngo-pharyngeal reflux and laryngeal carcinoma is currently debated. Chronic inflammation is a mutagen factor confirmed in the cancerogenesis of various tumours. Aim of the present study was to evaluate, in an objective and consecutive way, with 24h multi-electrode pH-metry the presence of proximal and distal oesophageal reflux in patients presenting pre-cancerosis or squamous cell laryngeal and/or pharyngeal carcinomas. From our data, a strict correlation emerged between laryngo-pharyngeal reflux and neoplasias of the upper airways, documented through multi-electrode pH-metry. Data emerging from this study would seem to support the theory that the protracted exposure (> 20 years) to biliary reflux would represent a statistically significant added risk factor in the precancerous lesions and squamous pharyngo-laryngeal carcinoma as it occurs at oesophageal level. Moreover, a significant statistical association (p < 0.0001) emerged between laryngeal carcinoma and previous gastro-resection (odds ratio 3.8).
摘要
目前，喉咽反流与喉癌之间的相关性存在争议。慢性炎症是在各种肿瘤发生过程中得到证实的诱变因素。本研究的目的是以客观且连续的方式，通过24小时多电极pH测量法评估患有癌前病变或鳞状细胞喉癌和/或咽癌的患者近端和远端食管反流的情况。从我们的数据来看，通过多电极pH测量法记录到，喉咽反流与上呼吸道肿瘤之间存在密切相关性。该研究得出的数据似乎支持这样一种理论，即长期暴露（>20年）于胆汁反流是食管水平发生的癌前病变和鳞状喉咽癌中具有统计学意义的额外危险因素。此外，喉癌与既往胃切除术之间存在显著的统计学关联（p<0.0001）（比值比为3.8）。
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