Liu Danling, Qian Tingting, Sun Shan, Jiang Jack J
Otorhinolaryngology Department, ENT Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, NHC Key Laboratory of Hearing Medicine Research, Fudan University, Shanghai 200032, People's Republic of China.
Department of Surgery, Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Medical School, Madison, WI 53792-7375, USA.
J Inflamm Res. 2021 Jan 5;13:1291-1304. doi: 10.2147/JIR.S282809. eCollection 2020.
The upper aerodigestive tract (UAT) is the first line of defense against environmental stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular junctions, epithelial cells, and immune cells are the major constituents of this defensive mucosal barrier. Laryngopharyngeal reflux (LPR) is recognized as an independent risk factor for UAT mucosal disorders, and in this review, we describe the components and functions of the mucosal barrier and the results of LPR-induced mucosal inflammation in the UAT. We discuss the interactions between the refluxate and the mucosal components and the mechanisms through which these damaging events disrupt and alter the mucosal barriers. In addition, we discuss the dynamic alterations in the mucosal barrier that might be potential therapeutic targets for LPR-induced disorders.
上呼吸道消化道（UAT）是抵御抗原、微生物、吸入物、食物等环境应激的第一道防线，黏液、细胞间连接、上皮细胞和免疫细胞是这种防御性黏膜屏障的主要组成部分。喉咽反流（LPR）被认为是UAT黏膜疾病的独立危险因素，在本综述中，我们描述了黏膜屏障的组成和功能以及LPR诱导的UAT黏膜炎症的结果。我们讨论了反流物与黏膜成分之间的相互作用以及这些损伤事件破坏和改变黏膜屏障的机制。此外，我们还讨论了黏膜屏障的动态变化，这些变化可能是LPR诱导疾病的潜在治疗靶点。
