Kligman E W
Department of Family and Community Medicine, University of Arizona College of Medicine, Tucson 85724.
West J Med. 1992 Jan;156(1):45-9.
Because of limited clinical investigations addressing the effectiveness of intervention to reduce known risk factors, it is difficult for primary care physicians to decide on which coronary heart disease risk factors to continue to screen for among older patients. The recently published report of the United States Preventive Services Task Force, using explicit screening criteria, has recommended that several risk factors be investigated for use among older adults. Recent longitudinal studies have found that a number of risk factors persist with advancing age-hypertension, left ventricular hypertrophy, impaired glucose metabolism, elevated cholesterol levels, obesity, smoking, physical inactivity, decline in vital capacity, and increased heart rate. Screening to identify many of these risks and treatment and counseling to modify them appear to improve survival. Evidence is less clear that diabetes mellitus and elevated cholesterol levels have the same significance for men and women as they age. Left ventricular hypertrophy and diabetes seem particularly important as risk factors for older women, whereas a high heart rate may be a greater risk for men.
由于针对降低已知风险因素的干预措施有效性的临床研究有限,初级保健医生难以决定在老年患者中继续筛查哪些冠心病风险因素。美国预防服务工作组最近发表的报告,使用明确的筛查标准,建议对一些风险因素进行调查,以便在老年人中使用。最近的纵向研究发现,随着年龄增长,一些风险因素持续存在,包括高血压、左心室肥厚、糖代谢受损、胆固醇水平升高、肥胖、吸烟、身体活动不足、肺活量下降和心率加快。筛查以识别其中许多风险,并进行治疗和咨询以改变这些风险,似乎可以提高生存率。关于糖尿病和胆固醇水平升高对男性和女性随着年龄增长的意义是否相同,证据尚不清楚。左心室肥厚和糖尿病似乎是老年女性特别重要的风险因素,而高心率可能对男性构成更大风险。