• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

An emulsion of sulfoquinovosylacylglycerol with long-chain alkanes increases its permeability to tumor cells.

作者信息

Aoki Satoko, Ohta Keisuke, Matsumoto Kenjiro, Sakai Hideki, Abe Masahiko, Miura Masahiko, Sugawara Fumio, Sakaguchi Kengo

机构信息

Department of Applied of Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba-ken 278-8510, Japan.

出版信息

J Membr Biol. 2006;213(1):11-8. doi: 10.1007/s00232-006-0054-x. Epub 2007 Mar 8.

DOI:10.1007/s00232-006-0054-x
PMID:17347779
Abstract

The alpha-anomer form of sulfoquinovosyl-monoacylglycerol with a saturated C18 fatty acid (alpha-SQMG-C(18:0)) is a natural sulfolipid that is a clinically promising antitumor agent. It forms vesicles, micelles or an emulsion in water, depending on several physicochemical conditions. The type of aggregate formed appears to strongly influence the bioactivity level. Thus, we investigated the nature of the aggregates in relation to their bioactivities. The structure of the alpha-SQMG-C(18:0) assembly was greatly affected by the type of additive used in the preparation. Emulsification with ethanol and n-decane might be more effective at inhibiting tumor cell growth than the micelle or vesicle preparations. alpha-SQMG-C(18:0) formed an "emulsion-like-aggregate" in ethanol containing an n-decane concentration in the range of 1.03-103 mM: . These ethanol/n-alkane/alpha-SQMG-C(18:0) aggregates inhibited cell growth in a dose-dependent manner, under optimum conditions (i.e., ethanol containing 103 mM: of n-decane or n-dodecane dispersed in phosphate-buffered saline or culture medium). Based on these data, we discuss the relationship between the molecular action of and antitumor activity by alpha-SQMG-C(18:0).

摘要

相似文献

1
An emulsion of sulfoquinovosylacylglycerol with long-chain alkanes increases its permeability to tumor cells.
J Membr Biol. 2006;213(1):11-8. doi: 10.1007/s00232-006-0054-x. Epub 2007 Mar 8.
2
Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols.新型哺乳动物DNA聚合酶抑制剂——合成磺基喹喔啉基酰基甘油的构效关系
Jpn J Cancer Res. 2000 Oct;91(10):1073-83. doi: 10.1111/j.1349-7006.2000.tb00887.x.
3
Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.乳化磺基喹喔啉基酰基甘油对哺乳动物DNA聚合酶的抑制作用。
Lipids. 2003 Oct;38(10):1065-74. doi: 10.1007/s11745-006-1162-1.
4
Mechanism of cell cycle arrest by sulfoquinovosyl monoacylglycerol with a C18-saturated fatty acid (C18-SQMG).含C18饱和脂肪酸的磺基喹喔啉单酰甘油（C18-SQMG）诱导细胞周期停滞的机制
Biochem Pharmacol. 2004 Apr 1;67(7):1373-80. doi: 10.1016/j.bcp.2003.12.004.
5
Structure-function relationship of synthetic sulfoquinovosyl-acylglycerols as mammalian DNA polymerase inhibitors.合成磺基喹喔啉基酰基甘油作为哺乳动物DNA聚合酶抑制剂的结构-功能关系
Arch Biochem Biophys. 2002 Jul 15;403(2):229-36. doi: 10.1016/s0003-9861(02)00219-9.
6
Specific interaction between an oligosaccharide on the tumor cell surface and the novel antitumor agents, sulfoquinovosylacylglycerols.
Biochem Biophys Res Commun. 2001 Nov 9;288(4):893-900. doi: 10.1006/bbrc.2001.5852.
7
Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol, targeting angiogenesis.一种新型抗肿瘤硫脂3'-磺基喹诺糖基-1'-单酰甘油通过靶向血管生成对Tie2基因的下调作用
Cancer Sci. 2008 May;99(5):1063-70. doi: 10.1111/j.1349-7006.2008.00785.x.
8
A novel DNA polymerase inhibitor and a potent apoptosis inducer: 2-mono-O-acyl-3-O-(alpha-D-sulfoquinovosyl)-glyceride with stearic acid.
Biochim Biophys Acta. 2003 Jan 31;1645(1):72-80. doi: 10.1016/s1570-9639(02)00521-6.
9
Studies on a novel DNA polymerase inhibitor group, synthetic sulfoquinovosylacylglycerols: inhibitory action on cell proliferation.新型DNA聚合酶抑制剂组——合成磺基喹喔啉基酰基甘油的研究：对细胞增殖的抑制作用
Mutat Res. 2000 May 8;467(2):139-52. doi: 10.1016/s1383-5718(00)00028-0.
10
Effects of DNA polymerase inhibitory and antitumor activities of lipase-hydrolyzed glycolipid fractions from spinach.菠菜中脂肪酶水解糖脂组分的DNA聚合酶抑制及抗肿瘤活性作用
J Nutr Biochem. 2005 Feb;16(2):121-8. doi: 10.1016/j.jnutbio.2004.08.005.

引用本文的文献

1
Proliferative Effect of Aqueous Extract of Sea Cucumber () Body Wall on Human Umbilical Cord Mesenchymal Stromal/Stem Cells.海参体壁水提物对人脐带间充质干细胞的增殖作用。
Mar Drugs. 2023 Apr 26;21(5):267. doi: 10.3390/md21050267.
2
Preparation, Supramolecular Aggregation and Immunological Activity of the Bona Fide Vaccine Adjuvant Sulfavant S.磺胺多辛纳米混悬剂的制备、超分子聚集及免疫活性
Mar Drugs. 2020 Aug 29;18(9):451. doi: 10.3390/md18090451.
3
Diasteroselective Colloidal Self-Assembly Affects the Immunological Response of the Molecular Adjuvant Sulfavant.

本文引用的文献

1
Alpha-sulfoquinovosylmonoacylglycerol is a novel potent radiosensitizer targeting tumor angiogenesis.α-磺基喹诺糖基单酰甘油是一种新型的、靶向肿瘤血管生成的强效放射增敏剂。
Cancer Res. 2006 Feb 15;66(4):2287-95. doi: 10.1158/0008-5472.CAN-05-2209.
2
Inhibition of CD62L+ T-cell response in vitro via a novel sulfo-glycolipid, beta-SQAG9 liposome that binds to CD62L molecule on the cell surface.通过一种新型的磺基糖脂β-SQAG9脂质体抑制体外CD62L+ T细胞反应，该脂质体可与细胞表面的CD62L分子结合。
Cell Immunol. 2004 Nov-Dec;232(1-2):105-15. doi: 10.1016/j.cellimm.2005.02.002. Epub 2005 Apr 2.
3
Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents.
非对映选择性胶体自组装影响分子佐剂磺香草醛的免疫反应。
ACS Omega. 2019 Apr 30;4(4):7807-7814. doi: 10.1021/acsomega.8b03304.
哺乳动物有丝分裂着丝粒相关驱动蛋白（MCAK）：磺基喹喔啉基酰基甘油新型抗肿瘤和免疫抑制剂的新分子靶点。
FEBS J. 2005 May;272(9):2132-40. doi: 10.1111/j.1742-4658.2005.04600.x.
4
Mechanism of the immunosuppressive effect in vivo of novel immunosuppressive drug beta-SQAG9, which inhibits the response of the CD62L+ T-cell subset.新型免疫抑制药物β-SQAG9在体内的免疫抑制作用机制，该药物可抑制CD62L+ T细胞亚群的反应。
Transplant Proc. 2005 Jan-Feb;37(1):139-42. doi: 10.1016/j.transproceed.2004.12.204.
5
Monolayer membranes and bilayer vesicles characterized by alpha- and beta-anomer of sulfoquinovosyldiacyglycerol (SQDG).以磺基喹喔啉二酰甘油（SQDG）的α-和β-异头物为特征的单层膜和双层囊泡。
Chem Phys Lipids. 2005 Feb;133(2):203-14. doi: 10.1016/j.chemphyslip.2004.10.004. Epub 2004 Nov 30.
6
Design of vesicles of 1,2-di-O-acyl-3-O-(beta-D-sulfoquinovosyl)-glyceride bearing two stearic acids (beta-SQDG-C18), a novel immunosuppressive drug.新型免疫抑制药物1,2 - 二 - O - 酰基 - 3 - O -（β - D - 磺基喹诺糖基）甘油酯（β - SQDG - C18）含两个硬脂酸的囊泡设计
Biochem Pharmacol. 2004 Dec 15;68(12):2379-86. doi: 10.1016/j.bcp.2004.08.020.
7
A sulphoquinovosyl diacylglycerol is a DNA polymerase epsilon inhibitor.磺基喹诺糖基二酰基甘油是一种DNA聚合酶ε抑制剂。
Biochem J. 2003 Feb 15;370(Pt 1):299-305. doi: 10.1042/BJ20021737.
8
Anti-tumor effect of chemically synthesized sulfolipids based on sea urchin's natural sulfonoquinovosylmonoacylglycerols.基于海胆天然磺基喹喔啉单酰甘油的化学合成硫脂的抗肿瘤作用
Jpn J Cancer Res. 2002 Jan;93(1):85-92. doi: 10.1111/j.1349-7006.2002.tb01204.x.
9
Synthesis of sulfoquinovosylacylglycerols, inhibitors of eukaryotic DNA polymerase alpha and beta.
Bioorg Med Chem. 2001 Feb;9(2):367-76. doi: 10.1016/s0968-0896(00)00252-2.
10
Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols.新型哺乳动物DNA聚合酶抑制剂——合成磺基喹喔啉基酰基甘油的构效关系
Jpn J Cancer Res. 2000 Oct;91(10):1073-83. doi: 10.1111/j.1349-7006.2000.tb00887.x.