Zhang Jun, Wang Sheng-Llin, Wang Xu-Xia, Huang Yan, Zhang Wen-Juan
Department of Orthodontics, School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China.
Shanghai Kou Qiang Yi Xue. 2006 Oct;15(5):521-5.
To investigate the effects of the recombinant human growth hormone (rh-GH) on the periodontal cells in the ovariectomized rats after orthodontic tooth movement.
Thirty seven-week-old SPF female Wistar rats were randomly divided into three groups: the control group, the ovariectomy-saline group (OVX-NS group) and the variectomy-GH group(OVX-GH group). Different treatments, including variectomy and injecting normal saline solution, were adminstrated on the rats of the three groups. The number of osteoclast in the compressed alveolar bone was counted on the fifteenth and thirtieth days. Histological changes were observed. The data was analyzed with ANOVA by SPSS12.0 software package.
By ANOVA analysis, there were significant differences in the number of osteoclast between the three groups in the same period. The number of osteoclast in the compressed alveolar bone of OVX-NS group was significantly more than that of the OVX-GH group (P < 0.05), and that of the control group was the least. In the same group, there wasn't significant difference between the rats killed 15 days later and 30 days later (P > 0.05). The trauma and inflammation of periodontal membrane of OVX-GH group had been significantly improved compared with the OVX-NS group.
It is suggested that injecting rh-GH can decrease the number of osteoclast in the compressed alveolar bone in the adult rats after orthodontic tooth movement. At the same time, it can improve the recovery of pathologic changes of periodontal tissue caused by the orthodontic force. There will be a synergetic effect between adult orthodontic treatment and rh-GH.
探讨重组人生长激素（rh-GH）对正畸牙移动后去卵巢大鼠牙周组织细胞的影响。
将37只7周龄SPF级雌性Wistar大鼠随机分为3组：对照组、去卵巢生理盐水组（OVX-NS组）和去卵巢生长激素组（OVX-GH组）。对3组大鼠分别进行不同处理，包括去卵巢及注射生理盐水。分别于第15天和第30天计数压缩牙槽骨中破骨细胞数量，观察组织学变化。采用SPSS12.0软件包进行方差分析。
方差分析结果显示，同期3组间破骨细胞数量差异有统计学意义。OVX-NS组压缩牙槽骨中破骨细胞数量明显多于OVX-GH组（P<0.05），对照组最少。同组内，术后15天处死与术后30天处死大鼠的破骨细胞数量差异无统计学意义（P>0.05）。与OVX-NS组相比，OVX-GH组牙周膜的创伤及炎症反应明显改善。
提示注射rh-GH可减少成年大鼠正畸牙移动后压缩牙槽骨中破骨细胞数量，同时可促进正畸力引起的牙周组织病理改变的恢复。成年正畸治疗与rh-GH之间可能存在协同作用。
