Pliskin A, Cualing H, Stenger R J
Department of Pathology, Nassau County Medical Center, East Meadow, NY 11554.
Arch Pathol Lab Med. 1992 Jan;116(1):105-7.
An 82-year-old woman developed a well-differentiated squamous cell carcinoma that apparently arose in two discrete congenital cysts of the liver. Both cysts were lined predominantly by stratified squamous epithelium with extensive areas of dysplasia and foci of transition to in situ carcinoma and overt exophytic and infiltrating squamous cell carcinoma. A third intrahepatic cyst was lined entirely by bile duct-type epithelium and contained no tumor. The liver was massively infiltrated by the carcinoma, and there were metastases to the lymph nodes, lung, and bone marrow. Since a search for an alternative primary tumor site was unrevealing, the authors interpret this as a unique case of primary squamous cell carcinoma originating in congenital cysts of the liver.
一名82岁女性患有一种高分化鳞状细胞癌，该肿瘤显然起源于肝脏两个不相连的先天性囊肿。两个囊肿主要内衬复层鳞状上皮，有广泛的发育异常区域，并有向原位癌转变的病灶以及明显的外生性和浸润性鳞状细胞癌病灶。第三个肝内囊肿完全由胆管型上皮内衬，未发现肿瘤。肝脏被癌广泛浸润，并转移至淋巴结、肺和骨髓。由于未找到其他原发肿瘤部位，作者将此解释为起源于肝脏先天性囊肿的原发性鳞状细胞癌的独特病例。
