Glass D, Roffe L, Maini R N, Wraith D G, Nuki G
Clin Exp Immunol. 1975 Apr;20(1):55-63.
Lymphocyte transformation to 1-24ACTH, as assessed by the incorporation of tritiated thymidine, has been demonstrated to be associated with severe adverse reactions occurring in patients receiving a Zn-linked 1-24ACTH preparation (Tetra cosactrin depot, 'Synacthen'). Antibodies measured with an isotope-binding assay occurred commonly in all patients receiving therapy and did not correlate with adverse reactions. Lymphocyte transformation with the 1-24ACTH polypeptide, a part of the naturally occurring ACTH molecule, has not been previously recorded. The significance of antibodies and cell-mediated immunity to this polypeptide hormone is discussed.
通过氚标记胸腺嘧啶核苷掺入法评估，淋巴细胞对1 - 24促肾上腺皮质激素（ACTH）的转化已被证明与接受锌连接的1 - 24ACTH制剂（长效促皮质素，“赛可同”）的患者发生的严重不良反应有关。用同位素结合测定法测得的抗体在所有接受治疗的患者中普遍存在，且与不良反应无关。此前尚未记录到淋巴细胞对1 - 24ACTH多肽（天然存在的ACTH分子的一部分）的转化情况。本文讨论了针对这种多肽激素的抗体和细胞介导免疫的意义。
