Cao Shugeng, Brodie Peggy J, Miller James S, Ratovoson Fidy, Callmander Martin W, Randrianasolo Sennen, Rakotobe Etienne, Rasamison Vincent E, Suh Edward M, TenDyke Karen, Kingston David G I
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA.
J Nat Prod. 2007 Jun;70(6):1064-7. doi: 10.1021/np0701428. Epub 2007 Jun 5.
Bioassay-guided fractionation of an ethanol extract obtained from the Madagascar plant Elaeodendron sp. led to the isolation of two new cardenolides, elaeodendrosides T and U (1 and 2). The structures of the new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1, 3, 4, and 5 showed significant antiproliferative activity against A2780 human ovarian cancer cells with IC50 values of 0.085, 0.019, 0.19, and 0.10 microM, respectively, while compounds 2 and 6 were less active.
对从马达加斯加植物刺榄属植物中获得的乙醇提取物进行生物测定导向的分级分离，得到了两种新的强心苷，刺榄苷T和U（1和2）。通过一维和二维核磁共振实验以及质谱对新化合物的结构进行了阐明。化合物1、3、4和5对A2780人卵巢癌细胞显示出显著的抗增殖活性，IC50值分别为0.085、0.019、0.19和0.10微摩尔，而化合物2和6的活性较低。
