Babri Shirin, Badie Hamid Gholamipour, Khamenei Saeed, Seyedlar Mehdi Ordikhani
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Brain Cogn. 2007 Jun;64(1):86-91. doi: 10.1016/j.bandc.2007.01.002. Epub 2007 Mar 8.
The main impacts of insulin favor the peripheral organs. Although it functions as a neuropeptide, insulin possesses also some central effects. The aim of this study was to determine the effect of intrahippocampal infusion of insulin on passive avoidance learning in healthy male rats. Thirty male wistar rats were divided into three groups (n=10 each). The experimental group had posttraining insulin infusion into the CA1 region of dorsal hippocampus, after which they were compared with sham (saline) and control (intact) groups. Insulin treated animals had greater latency to enter the dark compartment in compare with saline treated (p=0.023) or control groups (p=0.017). Upon our results, we concluded that intrahippocampal injections of insulin may enhance memory for a simple learning task which supports the concept that insulin possibly plays an endogenous role in memory formation.
胰岛素的主要作用集中在外周器官。尽管胰岛素作为一种神经肽发挥作用，但它也具有一些中枢效应。本研究的目的是确定海马体内注射胰岛素对健康雄性大鼠被动回避学习的影响。30只雄性Wistar大鼠被分为三组（每组n = 10）。实验组在训练后将胰岛素注入背侧海马的CA1区，之后与假手术组（注射生理盐水）和对照组（未处理）进行比较。与注射生理盐水的组（p = 0.023）或对照组（p = 0.017）相比，接受胰岛素治疗的动物进入暗室的潜伏期更长。基于我们的研究结果，我们得出结论，海马体内注射胰岛素可能会增强对简单学习任务的记忆，这支持了胰岛素可能在记忆形成中发挥内源性作用的观点。
