尿毒症大鼠的胸腺淋巴细胞及胸腺素5组分的体内作用
Thymus lymphocytes in uraemic rats and the effect of thymosin fraction 5 in vivo.
作者信息
Ikemoto S, Kamizuru M, Hayahara N, Okamoto S, Wada S, Kishimoto T, Maekawa M
机构信息
Department of Urology, Osaka Teishin Hospital, Japan.
出版信息
Clin Exp Immunol. 1992 Feb;87(2):220-3. doi: 10.1111/j.1365-2249.1992.tb02978.x.
Thymus lymphocyte subsets in uraemic rats were studied using monoclonal antibodies. Severe and moderate uraemia was induced in rats, and sham-operated and normal rats were used as the controls. As a result, the weight of the thymus decreased in uraemic rats. As for lymphocyte subsets, the frequency of W3/25+OX8+ decreased and those of W3/25-OX8-, W3/25+OX8- and W3/25- OX8+ relatively increased in uraemic rats. All these changes were more significant in severely uraemic than in moderately uraemic rats. When thymosin fraction 5 (TF5) was administered to severely uraemic rats, the weight of the thymus increased and the lymphocytes subsets normalized. These results suggest that uraemia may cause a maturational impairment of thymus lymphocytes by the depression of thymic hormone secretion.
采用单克隆抗体研究了尿毒症大鼠胸腺淋巴细胞亚群。在大鼠中诱导出重度和中度尿毒症，并将假手术大鼠和正常大鼠作为对照。结果，尿毒症大鼠胸腺重量减轻。至于淋巴细胞亚群，尿毒症大鼠中W3/25+OX8+的频率降低，而W3/25-OX8-、W3/25+OX8-和W3/25-OX8+的频率相对增加。所有这些变化在重度尿毒症大鼠中比在中度尿毒症大鼠中更显著。当给重度尿毒症大鼠注射胸腺素组分5（TF5）时，胸腺重量增加，淋巴细胞亚群恢复正常。这些结果表明，尿毒症可能通过抑制胸腺激素分泌导致胸腺淋巴细胞成熟障碍。
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