Ikemoto S, Kishimoto T, Wada S, Hayahara N, Maekawa M
Department of Urology, Osaka City University Medical School, Japan.
Clin Exp Immunol. 1990 Jun;80(3):474-7. doi: 10.1111/j.1365-2249.1990.tb03312.x.
Cellular immunity of thymus lymphocytes in uraemic rats was studied. Severe and moderate uraemia was induced in rats, and sham-operated and normal rats were used as the controls. As a result, the response of thymus lymphocytes to concanavalin A (Con A) significantly decreased in severely uraemic rats, but did not change in moderately uraemic rats. However, when the thymus lymphocytes were pretreated with thymosin fraction 5, the response to Con A was ameliorated in severely uraemic rats. There was a significant correlation between the effect of thymosin fraction 5 on Con A response and Con A response of thymus lymphocytes. In addition, serum from severe uraemic rats suppressed the response of normal thymus lymphocytes to Con A. These results indicate that severe uraemia may cause an impairment in maturation of thymus lymphocytes, which can be improved by thymosin fraction 5 in vitro.
对尿毒症大鼠胸腺淋巴细胞的细胞免疫进行了研究。在大鼠中诱导出重度和中度尿毒症，并将假手术大鼠和正常大鼠作为对照。结果，重度尿毒症大鼠胸腺淋巴细胞对刀豆蛋白A（Con A）的反应显著降低，而中度尿毒症大鼠则无变化。然而，当胸腺淋巴细胞用胸腺素5组分预处理时，重度尿毒症大鼠对Con A的反应得到改善。胸腺素5组分对Con A反应的作用与胸腺淋巴细胞的Con A反应之间存在显著相关性。此外，重度尿毒症大鼠的血清抑制了正常胸腺淋巴细胞对Con A的反应。这些结果表明，重度尿毒症可能导致胸腺淋巴细胞成熟受损，而胸腺素5组分在体外可改善这种情况。
