Braet Filip, Nagatsuma Keissuke, Saito Masaya, Soon Lilian, Wisse Eddie, Matsuura Tomokazu
World J Gastroenterol. 2007 Feb 14;13(6):821-5. doi: 10.3748/wjg.v13.i6.821.
Colorectal cancer (CRC) is a common malignant disease and the severe nature of cases in men and women who develop colorectal cancer makes this an important socio-economic health issue. Major challenges such as understanding and modeling colorectal cancer pathways rely on our understanding of simple models such as outlined in this paper. We discuss that the development of novel standardized approaches of multidimensional (correlative) biomolecular microscopy methods facilitates the collection of (sub) cellular tissue information in the early onset of colorectal liver metastasis and that this approach will be crucial in designing new effective strategies for CRC treatment. The application of X-ray micro-computed tomography and its potential in correlative imaging of the liver vasculature will be discussed.
结直肠癌（CRC）是一种常见的恶性疾病，男性和女性患结直肠癌的严重程度使其成为一个重要的社会经济健康问题。理解和构建结直肠癌通路等重大挑战依赖于我们对本文所述简单模型的理解。我们讨论了新型标准化多维（相关）生物分子显微镜方法的发展，有助于在结直肠癌肝转移早期收集（亚）细胞组织信息，并且这种方法对于设计新的结直肠癌有效治疗策略至关重要。还将讨论X射线显微计算机断层扫描的应用及其在肝脏血管系统相关成像中的潜力。
