红参甲醇提取物对大鼠脂多糖诱导的肝损伤的影响。
Effect of sun ginseng methanol extract on lipopolysaccharide-induced liver injury in rats.
作者信息
Kang K S, Yamabe N, Kim H Y, Yokozawa T
机构信息
Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
出版信息
Phytomedicine. 2007 Dec;14(12):840-5. doi: 10.1016/j.phymed.2007.01.002. Epub 2007 Mar 13.
Sun ginseng (SG) is heat-processed Panax ginseng C.A. Meyer steamed at 120 degrees C, which has ginsenoside-Rg(3), -Rk(1), and -Rg(5) as its main ginsenoside components. The effect of SG on lipopolysaccharide (LPS)-induced liver injury in rats was investigated in this study. Intravenous injection of LPS induced excessive nitric oxide (*NO) generation in serum and increased the hepatic mitochondrial thiobarbituric acid-reactive substance (TBA-RS) level. However, the elevated TBA-RS level was significantly lowered by 15 consecutive days of SG administrations. In addition, up-regulated hepatic inducible nitric oxide synthase and heme oxygenase 1 levels in LPS-treated control rats were significantly lowered and increased, respectively, by 100 mg/kg body weight/day of SG administration. These antioxidant effects were thought to be partially related to the deactivation of nuclear factor-kappaB by SG administration.
红参（SG）是将人参（Panax ginseng C.A. Meyer）在120摄氏度下蒸制进行热加工得到的，其主要人参皂苷成分是人参皂苷-Rg(3)、-Rk(1)和-Rg(5)。本研究调查了红参对脂多糖（LPS）诱导的大鼠肝损伤的影响。静脉注射LPS会导致血清中过量一氧化氮（*NO）生成，并使肝脏线粒体硫代巴比妥酸反应性物质（TBA-RS）水平升高。然而，连续15天给予红参后，升高的TBA-RS水平显著降低。此外，给予100 mg/kg体重/天的红参，可使LPS处理的对照大鼠肝脏中诱导型一氧化氮合酶上调水平显著降低，血红素加氧酶1水平显著升高。这些抗氧化作用被认为部分与红参给药使核因子-κB失活有关。
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