Paulson R J, Sauer M V, Francis M M, Macaso T M, Lobo R A
University of Southern California School of Medicine, Los Angeles.
Fertil Steril. 1992 Feb;57(2):290-3.
To describe the clinical experience of our center with in vitro fertilization (IVF) in unstimulated cycles and to provide a comparison to stimulated cycles.
Spontaneous ovulatory cycles were triggered with human chorionic gonadotropin in the midcycle, and 78 aspirations for IVF were performed, with the remainder of the IVF cycle proceeding in a standard manner.
The IVF program of the University of Southern California and the California Medical Center, Los Angeles, California.
Spontaneously ovulatory women (n = 46) with predominantly pelvic factor as their principal cause of infertility, under the age of 40, and no male factor.
Human chorionic gonadotropin administration in midcycle, follicle aspiration, IVF, and embryo transfer.
Embryo implantation and pregnancy.
Seventy-eight follicle aspirations resulted in 11 clinical (14%) and 9 ongoing (12%) pregnancies. The per embryo implantation rate was 13% clinical and 11% ongoing. There was no decrease in per cycle pregnancy rates (PRs) for up to three unstimulated cycles.
Unstimulated IVF is a viable alternative to stimulated cycles with PRs approximately one half those of stimulated cycles. It is reasonable to offer patients up to three cycles of unstimulated IVF without expecting a decrease in PRs.
描述我们中心在未刺激周期中进行体外受精（IVF）的临床经验，并与刺激周期进行比较。
在月经周期中期用人绒毛膜促性腺激素触发自然排卵周期，进行78次IVF取卵，IVF周期的其余部分按标准方式进行。
南加州大学和加利福尼亚州洛杉矶市加利福尼亚医学中心的IVF项目。
年龄在40岁以下、主要因盆腔因素导致不孕且无男性因素的自然排卵女性（n = 46）。
月经周期中期注射人绒毛膜促性腺激素、卵泡抽吸、IVF和胚胎移植。
胚胎着床和妊娠情况。
78次卵泡抽吸导致11例临床妊娠（14%）和9例持续妊娠（12%）。每个胚胎的着床率临床妊娠为13%，持续妊娠为11%。多达三个未刺激周期的每个周期妊娠率（PRs）没有下降。
未刺激IVF是刺激周期的一种可行替代方案，其PRs约为刺激周期的一半。为患者提供多达三个周期的未刺激IVF且不期望PRs下降是合理的。
