Ransom M X, Blotner M B, Bohrer M, Corsan G, Kemmann E
Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick.
Fertil Steril. 1994 Feb;61(2):303-7. doi: 10.1016/s0015-0282(16)56522-4.
To compare pregnancy rates (PR) per treatment cycle of controlled ovarian hyperstimulation (COH) patients receiving a single IUI with COH patients receiving two IUIs.
A prospective randomized trial of consecutively treated patients attending our infertility clinic for COH and IUI.
Patients undergoing COH by hMG and hCG were randomized to receive either one (group A) or two (group B) IUIs. Randomization was performed using a random number table. Group A IUIs were timed 35 hours after ovulatory hCG, whereas group B IUIs were performed 19 and 43 hours after hCG.
A total of 120 patients during 169 cycles were randomized between group A (90 cycles) and group B (79 cycles). Data analysis demonstrated no significant differences between groups A and B with respect to age, indications for COH, duration of hMG treatment, total amount of hMG administered, peak E2 levels, number of dominant follicles recruited, or mean number of total motile sperm inseminated. Pregnancy rates for groups A and B were 0.11 and 0.14, respectively. The size of our study population permits a conclusion that a 300%, 200%, or 100% difference in PR between the two groups does not exist (power 0.97, 0.80, or 0.61, respectively).
Among patients undergoing COH and IUI, increasing the frequency of insemination does not provide a significant increase in cycle pregnancy rate.
比较接受单次宫腔内人工授精（IUI）的控制性卵巢过度刺激（COH）患者与接受两次IUI的COH患者每个治疗周期的妊娠率（PR）。
一项对在我们不孕症诊所连续接受COH和IUI治疗的患者进行的前瞻性随机试验。
使用人绝经期促性腺激素（hMG）和人绒毛膜促性腺激素（hCG）进行COH的患者被随机分为接受一次IUI（A组）或两次IUI（B组）。使用随机数字表进行随机分组。A组在排卵性hCG后35小时进行IUI，而B组在hCG后19小时和43小时进行IUI。
共有120例患者在169个周期中被随机分为A组（90个周期）和B组（79个周期）。数据分析表明，A组和B组在年龄、COH指征、hMG治疗持续时间、hMG给药总量、E2峰值水平、募集的优势卵泡数量或平均总活动精子授精数量方面无显著差异。A组和B组的妊娠率分别为0.11和0.14。我们的研究人群规模使得可以得出结论，两组之间PR不存在300%、200%或100%的差异（检验效能分别为0.97、0.80或0.61）。
在接受COH和IUI的患者中，增加授精频率并不能显著提高周期妊娠率。
