在现代人类迁徙过程中，低效的线粒体单倍群是否被选择？一项使用细胞融合杂种细胞系线粒体耦合的模块化动力学分析的测试。
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines.
作者信息
Amo Taku, Brand Martin D
机构信息
MRC Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK.
出版信息
Biochem J. 2007 Jun 1;404(2):345-51. doi: 10.1042/BJ20061609.
Abstract
We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223-226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups.
摘要
我们介绍了一种针对线粒体DNA（mtDNA）变异体生物能量重要性的通用测试方法：对具有恒定核DNA但不同mtDNA的胞质杂种细胞中线粒体的氧化磷酸化进行模块化动力学分析。我们已将此测试应用于以下假设[鲁伊斯 - 佩西尼、米什马尔、布兰登、普罗卡乔和华莱士（2004年），《科学》303卷，223 - 226页]，即在现代人类向更寒冷气候辐射期间，特定的mtDNA单倍群（多态性的特定组合）会导致耦合效率降低，从而产生更少的ATP和更多的热量，但这些单倍群却受到了正向选择。与该假设的预测相反，北极单倍群的线粒体耦合效率与热带单倍群的线粒体相似，甚至更高。
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