Bigi Mohammad Ali Babaee, Aslani Amir, Shahrzad Shahab
Cardiology Department, Namazee Hospital, Shiraz University of Medical Sciences, PO Box 71935-1334, Shiraz, Islamic Republic of Iran.
Europace. 2007 Apr;9(4):252-5. doi: 10.1093/europace/eum023. Epub 2007 Mar 13.
Brugada syndrome is a cardiac channel abnormality that is associated with a high risk of ventricular fibrillation and sudden cardiac death and characterized by an electrocardiographic pattern of right bundle branch block and transient or persistent ST-segment elevation in leads V1-V3. No data regarding the frequency of Brugada syndrome exist in an Iranian population. The aim of this study was to determine the frequency of Brugada-type ECG pattern in southern Iran.
All patients presenting with palpitation were enrolled in the study. A Brugada-type ECG pattern was determined according to the criteria recommended by European Heart Association Molecular Basis of Arrhythmias Study Group. A total of 3895 patients (mean age 38.2 +/- 11.9 years, 54% women) met all study criteria. One hundred patients (2.56%) had Brugada-type ECG pattern. Of these, 21 patients (0.54%) had definite Brugada sign (Type 1 or Types 2 and 3 with conversion to Type 1 following procainamide test). Of 21 patients with definite Brugada sign, eight had Brugada syndrome, four had history of syncope, two had coved-type ECG in the family, one had polymorphic ventricular tachycardia, and one had history of sudden cardiac death in the family. Five patients underwent ICD implantation. The incidence of a Brugada-type ECG pattern was 2.43% in subjects between 17 and 30 years and 0.13% in subjects >30 years (P = 0.01).
Frequency of Brugada sign in an Iranian population presenting with palpitation is greater than some European countries and lower than a Japanese urban population.
布加综合征是一种心脏通道异常疾病，与室颤和心源性猝死的高风险相关，其特征为心电图表现为右束支传导阻滞以及V1 - V3导联出现短暂或持续性ST段抬高。伊朗人群中关于布加综合征发病率的数据尚无报道。本研究旨在确定伊朗南部布加型心电图模式的发生率。
所有有心悸症状的患者均纳入本研究。根据欧洲心脏病协会心律失常分子基础研究组推荐的标准确定布加型心电图模式。共有3895例患者（平均年龄38.2±11.9岁，54%为女性）符合所有研究标准。100例患者（2.56%）有布加型心电图模式。其中，21例患者（0.54%）有明确的布加征（1型或2型和3型经普鲁卡因胺试验后转变为1型）。在21例有明确布加征的患者中，8例患有布加综合征，4例有晕厥史，2例家族中有穹窿型心电图，1例有多形性室性心动过速，1例家族中有心源性猝死史。5例患者接受了植入式心律转复除颤器（ICD）植入。17至30岁受试者中布加型心电图模式的发生率为2.43%，>30岁受试者中为0.13%（P = 0.01）。
在有心悸症状的伊朗人群中，布加征的发生率高于一些欧洲国家，低于日本城市人群。
