Cohen Oren S, Vakil Eli, Tanne David, Nitsan Zeev, Schwartz Roseline, Hassin-Baer Sharon
Parkinson's disease and Movement Disorders Clinic, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Cogn Behav Neurol. 2007 Mar;20(1):68-72. doi: 10.1097/WNN.0b013e3180335f8e.
To test a possible association between the educational level (EL), cognitive performance, and neuropsychiatric features in Parkinson disease (PD).
An inverse association has been reported between EL and cognitive dysfunction in patients with senile dementia of Alzheimer type but it is yet unsettled whether education has a similar effect on cognition in PD.
Seventy-two PD patients (45 males, mean age 68.7+/-11.6 y) underwent a detailed neurologic examination, a battery of neuropsychologic tests, and questionnaires for the evaluation of psychosis, sleep disturbances, and depression. According to the number of educational years, patients were divided into 3 groups: low EL (0 to 8 y), (15 patients), intermediate EL (9 to 12 y) (28 patients), and high EL (>/=13 y) (29 patients).
Patients with a higher EL had a better cognitive function and an association was found between the patients' EL and their scores in various neuropsychologic tests mainly those sensitive to frontal lobe dysfunction. Low education was associated with an increased risk for hallucinations and a trend for more depression, delusions, and sleep disturbances.
The association between high educational attainment and the lower risk of cognitive dysfunction suggest that education might modulate cognitive performance in PD.
检验帕金森病（PD）患者的教育水平（EL）、认知表现和神经精神特征之间可能存在的关联。
据报道，阿尔茨海默型老年痴呆患者的EL与认知功能障碍呈负相关，但教育对PD患者认知功能是否有类似影响尚不确定。
72例PD患者（45例男性，平均年龄68.7±11.6岁）接受了详细的神经系统检查、一系列神经心理学测试以及评估精神病、睡眠障碍和抑郁的问卷。根据受教育年限，患者被分为3组：低EL组（0至8年）（15例患者）、中等EL组（9至12年）（28例患者）和高EL组（≥13年）（29例患者）。
EL较高的患者认知功能较好，且在各种神经心理学测试中，患者的EL与得分之间存在关联，主要是那些对额叶功能障碍敏感的测试。低教育水平与幻觉风险增加以及更多抑郁、妄想和睡眠障碍的趋势相关。
高教育程度与较低的认知功能障碍风险之间的关联表明，教育可能会调节PD患者的认知表现。
