Davis April D, Rudd Robert J, Bowen Richard A
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
J Infect Dis. 2007 Apr 15;195(8):1144-50. doi: 10.1086/512616. Epub 2007 Mar 5.
Between 1956 and 1977, 4 human cases of rabies virus infection were attributed to aerosolized rabies virus; however, little work has been done to address this topic since the late 1960s. Employing modern nebulization equipment coupled with serologic, cell culture, and molecular technology, we have continued the investigation into aerosolized rabies virus as a potential route of transmission. Laboratory mice and 2 species of bats were exposed, through aerosol, to 3 variants of rabies virus. All bats survived exposure to aerosolized rabies virus and produced rabies neutralizing antibody. Several mice died of rabies as a result of aerosol exposure. Antibody response was followed for 6 months before animals were given an intramuscular challenge of rabies virus. Poor protection from challenge was afforded in bats, despite the presence of neutralizing antibodies.
1956年至1977年间，有4例人类狂犬病病毒感染病例被认为是由雾化狂犬病病毒所致；然而，自20世纪60年代末以来，针对这一主题的研究甚少。我们利用现代雾化设备并结合血清学、细胞培养和分子技术，继续对雾化狂犬病病毒作为一种潜在传播途径展开调查。通过气溶胶，将实验室小鼠和两种蝙蝠暴露于3种狂犬病病毒变体。所有蝙蝠在暴露于雾化狂犬病病毒后存活下来，并产生了狂犬病中和抗体。几只小鼠因气溶胶暴露而死于狂犬病。在给动物进行狂犬病病毒肌肉注射攻击前，对抗体反应进行了6个月的跟踪观察。尽管存在中和抗体，但蝙蝠对攻击的保护作用较差。
