Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Nephrol. 2009 Nov-Dec;22(6):733-8.
The relationship between oxidant/antioxidant markers and proteinuria in type 2 diabetes is not clear, partly because of the potentially confounding effect of renal function which tends to become impaired during the course of diabetes.
We measured oxidized low-density lipoproteins (Ox-LDL), malondialdehyde (MDA) and extracellular superoxide dismutase (EC-SOD) in 142 type 2 diabetic patients (67 men). Renal function was assessed by plasma creatinine and glomerular filtration rate.
The group with proteinuria (n=78) was closely similar to the normoalbuminuric group (n=64) in age; body mass index; smoking habit; history of coronary artery disease; diabetes duration; use of lipid-lowering, antihypertensive and antidiabetic agents; blood pressure; fasting blood glucose; hemoglobin A1C and lipid profile. However, renal function was poorer and the proportion of males was higher in patients with proteinuria. When the effects of sex and renal function were controlled for, proteinuria was not a significant correlate of high Ox-LDL, but high MDA and EC-SOD levels were both significantly associated with proteinuria (p<0.01).
There are significant associations, independent of renal function status, between proteinuria and MDA as well as between proteinuria and EC-SOD in type 2 diabetes.
在 2 型糖尿病中，氧化应激标志物与蛋白尿之间的关系尚不清楚，部分原因是肾功能的潜在混杂效应，在糖尿病病程中往往会受损。
我们测量了 142 例 2 型糖尿病患者（67 名男性）的氧化型低密度脂蛋白（Ox-LDL）、丙二醛（MDA）和细胞外超氧化物歧化酶（EC-SOD）。肾功能通过血浆肌酐和肾小球滤过率评估。
蛋白尿组（n=78）与正常白蛋白尿组（n=64）在年龄、体重指数、吸烟习惯、冠心病史、糖尿病病程、降脂、降压和降糖药物的使用、血压、空腹血糖、糖化血红蛋白和血脂谱方面非常相似。然而，蛋白尿患者的肾功能较差，男性比例较高。当控制性别和肾功能的影响时，蛋白尿与高 Ox-LDL 无显著相关性，但高 MDA 和 EC-SOD 水平与蛋白尿显著相关（p<0.01）。
在 2 型糖尿病中，蛋白尿与 MDA 以及蛋白尿与 EC-SOD 之间存在显著关联，独立于肾功能状态。
