Jokhadze Malkhaz, Eristavi Lina, Kutchukhidze Jumber, Chariot Alain, Angenot Luc, Tits Monique, Jansen Olivia, Frédérich Michel
Department of Pharmacognosy, Faculty of Pharmacy, Tbilisi State Medical University, Akhvlediani Street 22, Tbilisi, Republic of Georgia.
Phytother Res. 2007 Jul;21(7):622-4. doi: 10.1002/ptr.2130.
Using an ethnomedical data approach, some Georgian plants, which are used in Georgian traditional medicine for cancer or non-cancer diseases, were collected and evaluated for cytotoxic activity. The cytotoxic effect of the methanol extracts of species from the genera Galanthus and Leucojum was evaluated in vitro on three human cell lines (Hela, ephitheloid cervix carcinoma; HCT-116, colon carcinoma; HL-60, acute myeloid leukaemia). Cell type cytotoxic specificity was observed for some extracts. Overall, the HCT-116 cells were much more sensitive to most of the extracts than were the other cell lines. Plants that showed pronounced cytotoxic activity will be further evaluated for the possible isolation of active antitumour compounds.
采用民族医学数据方法，收集了格鲁吉亚传统医学中用于治疗癌症或非癌症疾病的一些植物，并对其细胞毒性活性进行了评估。对雪花莲属和雪滴花属植物甲醇提取物的细胞毒性作用进行了体外评估，受试细胞系为三种人类细胞系（Hela，上皮样宫颈癌；HCT - 116，结肠癌；HL - 60，急性髓性白血病）。观察到某些提取物具有细胞类型细胞毒性特异性。总体而言，HCT - 116细胞对大多数提取物的敏感性远高于其他细胞系。对显示出明显细胞毒性活性的植物将进一步评估其活性抗肿瘤化合物的可能分离情况。
