Movahed Mohammad-Reza, Saito Yuji, Ahmadi-Kashani Mastaneh, Ebrahimi Ramin
Department of Medicine, Section of Cardiology, University of Arizona Sarver Heart Center, Tucson, Arizona, USA.
Cardiovasc Ultrasound. 2007 Mar 14;5:14. doi: 10.1186/1476-7120-5-14.
Mitral annulus calcification (MAC) is a common finding on echocardiographic examination. The goal of this study was to evaluate associations between MAC and cardiac abnormalities using a large echocardiographic database.
For this study we retrospectively reviewed 24,380 echocardiograms performed for clinical reasons between the years 1984 and 1998.
MAC was reported in 1,494 (6.1%) subjects. Using multivariate analysis, age, left ventricular hypertrophy (LVH), mitral regurgitation (MR), tricuspid regurgitation (TR), aortic stenosis (AS), left atrial (LA) enlargement and reversed E/A ratio were independently associated with MAC.)MAC was noted in 11.7 % of patients with MR vs. 4.3% without MR (OR: 2.0, CI 1.6-2.6, p < 0.0001), in 13.9% of those with TR vs. 4.5% without TR (OR: 3.8, CI 2.9-4.8, p < 0.0001), in 10.6% with LVH vs. 4.2% without LVH (OR: 1.9, CI 1.5-2.4, p < 0.0001), in 14.8% with AS vs. 5.5% without AS (OR: 1.4, CI 1.08-1.9, p = 0.01), in 9.4% with reversed E/A ratio vs. 3.8% without reversed E/A ratio (OR: 1.7, CI 1.4-2.2, p < 0.0001) and in 8.2% with LA enlargement vs. 4.8% without LA enlargement (OR: 1.3, CI 1.06-1.7, p = 0.02).
In our study, MAC independently correlated with significant structural heart abnormalities. This suggests that identification of MAC may serve as a marker for other cardiac structural disorders.
二尖瓣环钙化（MAC）是超声心动图检查中常见的发现。本研究的目的是使用一个大型超声心动图数据库评估MAC与心脏异常之间的关联。
在本研究中，我们回顾性分析了1984年至1998年间因临床原因进行的24380份超声心动图。
1494名（6.1%）受试者报告有MAC。采用多因素分析，年龄、左心室肥厚（LVH）、二尖瓣反流（MR）、三尖瓣反流（TR）、主动脉瓣狭窄（AS）、左心房（LA）扩大和E/A比值倒置与MAC独立相关。有MR的患者中11.7%有MAC，无MR的患者中为4.3%（OR：2.0，CI 1.6 - 2.6，p < 0.0001）；有TR的患者中13.9%有MAC，无TR的患者中为4.5%（OR：3.8，CI 2.9 - 4.8，p < 0.0001）；有LVH的患者中10.6%有MAC，无LVH的患者中为4.2%（OR：1.9，CI 1.5 - 2.4，p < 0.0001）；有AS的患者中14.8%有MAC，无AS的患者中为5.5%（OR：1.4，CI 1.08 - 1.9，p = 0.01）；有E/A比值倒置的患者中9.4%有MAC，无E/A比值倒置的患者中为3.8%（OR：1.7，CI 1.4 - 2.2，p < 0.0001）；有LA扩大的患者中8.2%有MAC，无LA扩大的患者中为4.8%（OR：1.3，CI 1.06 - 1.7，p = 0.02）。
在我们的研究中，MAC与显著的心脏结构异常独立相关。这表明MAC的识别可能作为其他心脏结构紊乱的一个标志物。
