哺乳动物寿命的激素调节。
Hormonal regulation of longevity in mammals.
作者信息
Brown-Borg Holly M
机构信息
Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA.
出版信息
Ageing Res Rev. 2007 May;6(1):28-45. doi: 10.1016/j.arr.2007.02.005. Epub 2007 Feb 20.
Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.
多种生物和环境因素会影响生物体的寿命。内分泌系统是哺乳动物中一个高度整合的生理系统，它调节新陈代谢、生长、繁殖以及对压力的反应等多种功能。因此，这个普遍存在的实体对衰老和寿命有着重大影响。在过去几年里，生长激素、胰岛素样生长因子-1和胰岛素信号通路一直处于衰老激素控制研究的前沿。其他激素，包括来自甲状腺和生殖系统的激素，也在寿命调节方面得到了研究。这些激素与人类长寿的相关性仍有待确定，然而来自酵母、线虫和果蝇等其他物种的证据表明，进化上高度保守的机制在起作用，内分泌系统是一个关键决定因素。
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