Second Hospital of Hebei Medical University, Shijiazhuang, China.
Front Endocrinol (Lausanne). 2023 Aug 2;14:1223529. doi: 10.3389/fendo.2023.1223529. eCollection 2023.
Aging is a biological process in which the environment interacts with the body to cause a progressive decline in effective physiological function. Aging in the human body can lead to a dysfunction of the vital organ systems, resulting in the onset of age-related diseases, such as neurodegenerative and cardiovascular diseases, which can seriously affect an individual's quality of life. The endocrine system acts on specific targets through hormones and related major functional factors in its pathways, which play biological roles in coordinating cellular interactions, metabolism, growth, and aging. Aging is the result of a combination of many pathological, physiological, and psychological processes, among which the endocrine system can achieve a bidirectional effect on the aging process by regulating the hormone levels in the body. In this paper, we explored the mechanisms of growth hormone, thyroid hormone, and estrogen in the aging process to provide a reference for the exploration of endocrine mechanisms related to aging.
衰老是一个生物学过程，在这个过程中，环境与身体相互作用，导致有效生理功能的逐渐衰退。人体的衰老可能导致重要器官系统功能失调，从而引发与年龄相关的疾病，如神经退行性疾病和心血管疾病，这可能严重影响个人的生活质量。内分泌系统通过其途径中的激素和相关主要功能因素作用于特定靶标，在协调细胞间相互作用、代谢、生长和衰老方面发挥着生物学作用。衰老是许多病理、生理和心理过程共同作用的结果，其中内分泌系统可以通过调节体内激素水平对衰老过程产生双向影响。本文探讨了生长激素、甲状腺激素和雌激素在衰老过程中的作用机制，为探索与衰老相关的内分泌机制提供了参考。
