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在从葡萄牙主要囊性纤维化中心分离出的洋葱伯克霍尔德菌复合体菌株中，洋葱伯克霍尔德菌的占比极高。

Exceptionally high representation of Burkholderia cepacia among B. cepacia complex isolates recovered from the major Portuguese cystic fibrosis center.

作者信息

Cunha Mónica V, Pinto-de-Oliveira Ana, Meirinhos-Soares Luís, Salgado Maria José, Melo-Cristino José, Correia Susana, Barreto Celeste, Sá-Correia Isabel

机构信息

IBB-Institute for Biological and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

出版信息

J Clin Microbiol. 2007 May;45(5):1628-33. doi: 10.1128/JCM.00234-07. Epub 2007 Mar 14.

DOI:10.1128/JCM.00234-07
PMID:17360834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865859/
Abstract

Burkholderia cepacia, a species found infrequently in cystic fibrosis (CF), was isolated from 85% of patients infected with bacteria of the B. cepacia complex that visited the major Portuguese CF center, in Lisbon, during 2003 to 2005. A detailed molecular analysis revealed that this was mainly due to two B. cepacia clones. These clones were indistinguishable from two strains isolated from intrinsically contaminated nonsterile saline solutions for nasal application, detected during routine market surveillance by the Portuguese Medicines and Health Products Authority.

摘要

洋葱伯克霍尔德菌在囊性纤维化（CF）患者中并不常见，但在2003年至2005年期间，从前往里斯本主要葡萄牙CF中心就诊的感染洋葱伯克霍尔德菌复合体细菌的患者中，85%分离出了该菌。详细的分子分析表明，这主要是由于两个洋葱伯克霍尔德菌克隆。这些克隆与葡萄牙药品和保健品管理局在常规市场监测期间检测到的从用于鼻腔的内在污染非无菌盐溶液中分离出的两个菌株无法区分。

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An outbreak of Burkholderia cepacia complex associated with intrinsically contaminated nasal spray.与内在污染的鼻腔喷雾相关的伯克霍尔德菌复合种暴发。
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Outbreak of Burkholderia cepacia bacteremia in immunocompetent children caused by contaminated nebulized sulbutamol in Saudi Arabia.沙特阿拉伯因雾化沙丁胺醇污染导致免疫功能正常儿童发生洋葱伯克霍尔德菌血症暴发。
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Sustained endemicity of Burkholderia cepacia complex in a pediatric institution, associated with contaminated ultrasound gel.小儿医疗机构中洋葱伯克霍尔德菌复合体的持续地方性流行，与超声凝胶污染有关。
Infect Control Hosp Epidemiol. 2006 Apr;27(4):362-6. doi: 10.1086/503343. Epub 2006 Mar 17.
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Transmission of Burkholderia cepacia complex: evidence for new epidemic clones infecting cystic fibrosis patients in Italy.洋葱伯克霍尔德菌复合体的传播：意大利感染囊性纤维化患者的新流行克隆的证据。
J Clin Microbiol. 2005 Oct;43(10):5136-42. doi: 10.1128/JCM.43.10.5136-5142.2005.
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A novel strategy for the isolation and identification of environmental Burkholderia cepacia complex bacteria.一种用于分离和鉴定环境洋葱伯克霍尔德菌复合体细菌的新策略。
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