Ratsimbasoa Arsène, Randriamanantena Arthur, Raherinjafy Rogelin, Rasoarilalao Noéline, Ménard Didier
Epidemiology Unit, and Malaria Unit Research, Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Am J Trop Med Hyg. 2007 Mar;76(3):481-5.
Field and laboratory studies were carried out in October and November 2005 to provide a comparative evaluation of the performance of three rapid malaria detection tests, two of which were recently introduced (the CareStart Malaria test and the SD Malaria Antigen Bioline test) and the well-known OptiMAL-IT test. Compared with microscopy, the sensitivity of the three tests to detect Plasmodium falciparum malaria was 97% for the CareStart Malaria test, 89.4% for the SD Malaria Antigen Bioline test, and 92.6% for the OptiMAL-IT test. The three tests were less sensitive in detecting non-P. falciparum infections, and the sensitivity decreased at levels of parasitemia<or=500 parasites/microL for P. falciparum and<or=5,000 parasites/microL for other Plasmodium spp. On the basis of World Health Organization recommendations, only the CareStart Malaria test and the OptiMAL-IT test had sensitivities greater than 95% for samples with parasitemias>or=100 parasites/microL.
2005年10月和11月开展了现场和实验室研究，以对三种快速疟疾检测试验的性能进行比较评估，其中两种是最近推出的（CareStart疟疾检测试验和SD疟疾抗原Bioline检测试验），还有著名的OptiMAL-IT检测试验。与显微镜检查相比，CareStart疟疾检测试验检测恶性疟原虫疟疾的灵敏度为97%，SD疟疾抗原Bioline检测试验为89.4%，OptiMAL-IT检测试验为92.6%。这三种试验在检测非恶性疟原虫感染时灵敏度较低，对于恶性疟原虫，当疟原虫血症水平≤500个寄生虫/微升，对于其他疟原虫属，当疟原虫血症水平≤5000个寄生虫/微升时，灵敏度会下降。根据世界卫生组织的建议，对于疟原虫血症≥100个寄生虫/微升的样本，只有CareStart疟疾检测试验和OptiMAL-IT检测试验的灵敏度大于95%。
