N-杂环卡宾配体在钴催化的6-卤代-1-己烯衍生物与格氏试剂的串联环化/交叉偶联反应中的应用

N-heterocyclic carbene ligands in cobalt-catalyzed sequential cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives with Grignard reagents.

作者信息

Someya Hidenori, Ohmiya Hirohisa, Yorimitsu Hideki, Oshima Koichiro

机构信息

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

出版信息

Org Lett. 2007 Apr 12;9(8):1565-7. doi: 10.1021/ol070392f. Epub 2007 Mar 16.

DOI:10.1021/ol070392f

PMID:17362026

Abstract

[reaction: see text] N-Heterocyclic carbene/cobalt systems effectively catalyze sequential cyclization/cross-coupling reactions of 6-halo-1-hexene derivatives with trialkylsilylmethyl and 1-alkynyl Grignard reagents, which phosphine and amine ligands did not promote.

摘要

[反应：见正文] N-杂环卡宾/钴体系能有效催化6-卤代-1-己烯衍生物与三烷基硅基甲基和1-炔基格氏试剂的串联环化/交叉偶联反应，而膦配体和胺配体无法促进该反应。