动脉内输注前列腺素期间对大鼠空肠水和钠分泌的刺激以及对葡萄糖吸收的抑制。
Stimulation of water and sodium secretion and inhibition of glucose absorption from the rat jejunum during intraarterial infusions of prostglandins.
作者信息
Coupar I M, McColl I
出版信息
Gut. 1975 Oct;16(10):759-65. doi: 10.1136/gut.16.10.759.
The effect of prostaglandins, isoprenaline and dibutyryl cyclic adenosine monophosphate (dibut cAMP) on the net transfer of water and Na+ and glucose absorption have been studied in the anaesthetized rat. The lumen of the jejunum was recirculated with a solution of normal saline containing D (+) glucose and phenosulphonphthalein. The superior mesenteric artery was perfused extracorporeally and drugs were infused into the arterial blood. Prostaglandin E1 (PGE1) at infusion rates of 2-5 X 10(-9) and 10(-8) mol/min induced a net secretion of water and Na+ which was significantly different from the infused control mean. Both water and Na+ secretion were dose-related. PGE1 induced slight but significant inhibition of glucose absorption at 10(-8) mol/min. This could either be a direct effect or secondary to solvent drag. PGE2 (2-5 X 10(-9) mol/min) and PGF2alpha (8 X 10(-9) mol/min) induced water and Na+ secretion, and inhibited glucose absorption but not significantly. Isoprenaline (10(-9) mol/min) and dibut cAMP (8 X 10(-9) mol/min) did not alter water, Na+ or glucose absorption.
在麻醉大鼠中研究了前列腺素、异丙肾上腺素和二丁酰环磷酸腺苷（二丁酰cAMP）对水和钠的净转运以及葡萄糖吸收的影响。空肠腔用含有D（+）葡萄糖和酚磺酞的生理盐水溶液进行再循环。肠系膜上动脉进行体外灌注，药物注入动脉血中。以2 - 5×10⁻⁹和10⁻⁸mol/min的输注速率输注前列腺素E1（PGE1）可引起水和钠的净分泌，这与输注对照平均值有显著差异。水和钠的分泌均与剂量相关。在10⁻⁸mol/min时，PGE1对葡萄糖吸收有轻微但显著的抑制作用。这可能是直接作用或继发于溶剂拖曳。前列腺素E2（2 - 5×10⁻⁹mol/min）和前列腺素F2α（8×10⁻⁹mol/min）可引起水和钠的分泌，并抑制葡萄糖吸收，但不显著。异丙肾上腺素（10⁻⁹mol/min）和二丁酰cAMP（8×10⁻⁹mol/min）不改变水、钠或葡萄糖的吸收。
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