胫骨孤立性骨转移作为子宫内膜腺癌的首发症状：一例病例报告及文献复习
Solitary bone metastasis in the tibia as a presenting sign of endometrial adenocarcinoma: a case report and the review of the literature.
作者信息
Kaya Ahmet, Olmezoglu Ali, Eren Cemal Suat, Bayol Umit, Altay Taskin, Karapinar Levent, Ozturk Hasan, Oztekin Deniz, Guvenli Yalcin, Karadogan Ilker
机构信息
S.B. Izmir - Tepecik Educational and Research Hospital, Izmir, Turkey.
出版信息
Clin Exp Metastasis. 2007;24(2):87-92. doi: 10.1007/s10585-007-9061-2. Epub 2007 Mar 16.
BACKGROUND
Metastasis to bone from endometrial adenocarcinoma is rare, when metastasises it usually locates in axial skeleton. Metastasis to extremities is extremely rare. Additionally the detection of the bone metastasis as a presenting feature is uncommon. In the present study we report the 10th cases of bone metastasis in the literature which located at tibial diaphysis and originated from endometrial adenocarcinoma as a presenting feature of the primary disease.
CASE
Single tibial lesion was observed in a 70 years old woman. Biopsy confirmed metastatic adenocarcinoma of the unknown origin. We couldn't find the primary origin with aggressive work-up. Tibial lesion regressed with radiotherapy. Endometrial adenocarcinoma is detected after the end of disease-free one year with the symptom of vaginal bleeding. After 47 months from initial tibial lesion and 35 months from gynaecologic operation, patient is still alive and disease free.
DISCUSSION
Patients with endometrial adenocarcinoma presenting an isolated skeletal metastasis may exhibit an unusual group with a better prognosis.
背景
子宫内膜腺癌骨转移罕见，转移时通常位于中轴骨骼。转移至四肢极为罕见。此外，以骨转移作为首发特征的情况并不常见。在本研究中，我们报告了文献中第10例位于胫骨干、起源于子宫内膜腺癌且作为原发疾病首发特征的骨转移病例。
病例
一名70岁女性被观察到胫骨有单个病灶。活检证实为来源不明的转移性腺癌。经过积极检查，我们未能找到原发灶。胫骨病灶经放疗后消退。在无病生存一年后，出现阴道出血症状，随后检测出子宫内膜腺癌。自最初胫骨病灶出现47个月以及妇科手术后35个月，患者仍然存活且无疾病。
讨论
表现为孤立性骨转移的子宫内膜腺癌患者可能构成一个预后较好的特殊群体。
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