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使用经人绒毛膜促性腺激素(HCG)预处理的不育男性的睾丸精子获得成功的妊娠结局。

A successful pregnancy outcome using testicular sperm from an infertile male pretreated with HCG.

作者信息

Cao Y-X, Zhang Z-G

机构信息

Reproduction Center, Department of Obstetrics, The First Affiliated Hospital, Anhui Medical University, Hefei, China.

出版信息

Arch Androl. 2007 Jan-Feb;53(1):1-3. doi: 10.1080/01485010600889076.

DOI:10.1080/01485010600889076
PMID:17364455
Abstract

A very rare case of successful pregnancy was reported using testicular sperm from a severely infertile man given the treatment of hCG in advance. Prior to treatment, no sperm were present in the ejaculate and testicle. hCG was administrated to the patient for spermatogenesis. After a period of hCG treatment, a few immature sperm were observed in the minced testicular specimen. A successful pregnancy was established by ICSI using the sperm. Treatment by administration of hCG to generate sperm followed by ICSI for the azoospermia patients was effective and practicable.

摘要

报道了一例非常罕见的成功妊娠病例,该病例使用了一名严重不育男子预先接受人绒毛膜促性腺激素(hCG)治疗后的睾丸精子。治疗前,精液和睾丸中均未发现精子。给患者使用hCG以促进精子发生。经过一段时间的hCG治疗后,在切碎的睾丸标本中观察到了一些未成熟精子。通过卵胞浆内单精子注射(ICSI)使用这些精子实现了成功妊娠。对无精子症患者先给予hCG以产生精子,然后进行ICSI治疗是有效且可行的。

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1
A successful pregnancy outcome using testicular sperm from an infertile male pretreated with HCG.使用经人绒毛膜促性腺激素(HCG)预处理的不育男性的睾丸精子获得成功的妊娠结局。
Arch Androl. 2007 Jan-Feb;53(1):1-3. doi: 10.1080/01485010600889076.
2
Recovery of spermatozoa after rFSH/hCG treatment, and subsequent ICSI/IVF, in a male with testicular atrophy due to severe congenital hypogonadotrophic hypogonadism.一名因严重先天性低促性腺激素性性腺功能减退导致睾丸萎缩的男性,经重组促卵泡生成素/人绒毛膜促性腺激素治疗后精子恢复,随后进行了卵胞浆内单精子注射/体外受精。
Arch Androl. 2006 Mar-Apr;52(2):135-8. doi: 10.1080/01485010500315891.
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[Testicular follicle-stimulating hormone receptors and effectiveness of human menopausal gonadotropin-human chorionic gonadotropin treatment in idiopathic male infertility].
Hinyokika Kiyo. 1988 Jun;34(6):957-61.
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[Control observations on andrological patients treated with HCG/HMG with special reference to spermatogram and somatic development].
Andrologia. 1981 May-Jun;13(3):198-206.
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引用本文的文献

1
Gonadotropins treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia: a single-center cohort study.在非梗阻性无精子症患者中行显微睾丸精子提取术前行促性腺激素治疗:一项单中心队列研究。
Reprod Biol Endocrinol. 2022 Apr 1;20(1):61. doi: 10.1186/s12958-022-00934-1.
2
Hormonal therapy for non-obstructive azoospermia: basic and clinical perspectives.非梗阻性无精子症的激素治疗:基础与临床视角
Reprod Med Biol. 2014 Sep 18;14(2):65-72. doi: 10.1007/s12522-014-0193-1. eCollection 2015 Apr.