新生小鼠实验性人疱疹病毒感染中的被动免疫
Passive immunization in experimental Herpesvirus hominis infection of newborn mice.
作者信息
Luyet F, Samra D, Soneji A, Marks M I
出版信息
Infect Immun. 1975 Dec;12(6):1258-61. doi: 10.1128/iai.12.6.1258-1261.1975.
Abstract
Infection of newborn mice with Herpesvirus hominis type 2(HVH-2) was used as an experimental model of disseminated HVH infection in newborn humans. Mice were challenged with 103 plaque-forming units of HVH-2 intranasally and were given 0.2 ml of rabbit serum intraperitoneally. Passive immunizations with rabbit anti-HVH-2 serum resulted in a significant decrease in mortality and prolongation of survival time. This effect correlated with the neutralizing antibody titer of the serum against HVH-2 and was more pronounced when immune serum was administered 1 h after infection as compared with 24 h. These results suggest that administration of high-titer anti-HVH-2 immunoglobulins shortly after delivery could afford significant protection to the newborn of a mother with genital HVH-2 infection.
摘要
用2型人疱疹病毒（HVH - 2）感染新生小鼠作为新生儿人HVH播散性感染的实验模型。给小鼠经鼻接种103个HVH - 2蚀斑形成单位，并腹腔注射0.2 ml兔血清。用兔抗HVH - 2血清进行被动免疫可显著降低死亡率并延长存活时间。这种效应与血清针对HVH - 2的中和抗体滴度相关，并且与感染后24小时给予免疫血清相比，感染后1小时给予免疫血清时这种效应更明显。这些结果表明，在分娩后不久给予高滴度抗HVH - 2免疫球蛋白可为患有生殖器HVH - 2感染的母亲的新生儿提供显著保护。
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