与年龄匹配的对照组相比，年轻的酒精依赖女性灌注减少。
Decreased perfusion in young alcohol-dependent women as compared with age-matched controls.
作者信息
Clark Camellia P, Brown Gregory G, Eyler Lisa T, Drummond Sean P A, Braun Deborah R, Tapert Susan F
机构信息
VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA.
出版信息
Am J Drug Alcohol Abuse. 2007;33(1):13-9. doi: 10.1080/00952990601082605.
Abstract
AIM
To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women.
METHODS
Eight alcohol dependent women and 8 controls (all ages 18-25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum.
RESULTS
Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions.
CONCLUSIONS
Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.
摘要
目的
利用磁共振成像（MRI）卓越的空间分辨率，研究年轻酒精依赖女性与正常女性之间脑灌注的差异。
方法
8名酒精依赖女性和8名对照者（年龄均为18 - 25岁）接受了单层面静息灌注加权MRI（与脑血流量成正比），扫描层面位于胼胝体上方。
结果
酒精依赖女性的前额叶和左侧顶叶区域灌注减少。
结论
此前尚未有关于年轻、身体健康的酒精依赖女性灌注减少的报道，但这与先前报道的酒精依赖中脑活动减少是一致的。
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