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Psychiatry Res. 2006 Apr 30;146(3):213-22. doi: 10.1016/j.pscychresns.2005.12.008. Epub 2006 Mar 20.
2
Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression?杏仁核灌注与重度抑郁症患者对部分睡眠剥夺的抗抑郁反应是否相关？
Psychiatry Res. 2006 Jan 30;146(1):43-51. doi: 10.1016/j.pscychresns.2005.09.007. Epub 2005 Dec 27.
3
Neuroimaging of gender differences in alcohol dependence: are women more vulnerable?酒精依赖中性别差异的神经影像学研究：女性更易受影响吗？
Alcohol Clin Exp Res. 2005 May;29(5):896-901. doi: 10.1097/01.alc.0000164376.69978.6b.
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BOLD and perfusion response to finger-thumb apposition after acetazolamide administration: differential relationship to global perfusion.乙酰唑胺给药后对拇指对掌动作的血氧水平依赖性功能磁共振成像和灌注反应：与整体灌注的差异关系
J Cereb Blood Flow Metab. 2003 Jul;23(7):829-37. doi: 10.1097/01.WCB.0000071887.63724.B2.
5
Regional cerebral blood flow measured by the resting and vascular reserve (RVR) method in chronic alcoholics.通过静息和血管储备（RVR）方法测量慢性酒精中毒患者的局部脑血流量。
Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):95S-99S. doi: 10.1097/01.ALC.0000026984.37262.82.
6
Cerebral perfusion defects in combined cocaine and alcohol dependence.可卡因与酒精合并依赖中的脑灌注缺损
Drug Alcohol Depend. 2002 Sep 1;68(1):95-104. doi: 10.1016/s0376-8716(02)00109-6.
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fMRI measurement of brain dysfunction in alcohol-dependent young women.酒精依赖年轻女性脑功能障碍的功能磁共振成像测量
Alcohol Clin Exp Res. 2001 Feb;25(2):236-45.
8
Automated Talairach atlas labels for functional brain mapping.用于功能性脑图谱的自动Talairach图谱标签
Hum Brain Mapp. 2000 Jul;10(3):120-31. doi: 10.1002/1097-0193(200007)10:3<120::aid-hbm30>3.0.co;2-8.
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Regional brain metabolism during alcohol intoxication.酒精中毒期间的局部脑代谢
Alcohol Clin Exp Res. 2000 Jun;24(6):822-9.
10
Psychometric evaluation of the Customary Drinking and Drug Use Record (CDDR): a measure of adolescent alcohol and drug involvement.习惯性饮酒和药物使用记录（CDDR）的心理测量评估：一种衡量青少年酒精和药物使用情况的方法。
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与年龄匹配的对照组相比，年轻的酒精依赖女性灌注减少。

Decreased perfusion in young alcohol-dependent women as compared with age-matched controls.

作者信息

Clark Camellia P, Brown Gregory G, Eyler Lisa T, Drummond Sean P A, Braun Deborah R, Tapert Susan F

机构信息

VA San Diego Healthcare System, Department of Psychiatry, University of California at San Diego, San Diego, California, USA.

出版信息

Am J Drug Alcohol Abuse. 2007;33(1):13-9. doi: 10.1080/00952990601082605.

DOI:10.1080/00952990601082605
PMID:17366242
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2289781/
Abstract

AIM

To use the superior spatial resolution of magnetic resonance imaging (MRI) to examine differences in cerebral perfusion between young alcohol dependent and normal women.

METHODS

Eight alcohol dependent women and 8 controls (all ages 18-25) received single-slice resting perfusion-weighted MRI (directly proportional to brain blood flow), with slices located above the corpus callosum.

RESULTS

Alcohol-dependent women had decreased perfusion in prefrontal and left parietal regions.

CONCLUSIONS

Reduced perfusion has not previously been reported in young, physically healthy alcohol dependent females, yet is consistent with previously reported decreased cerebral activity in alcohol dependence.

摘要

目的

利用磁共振成像（MRI）卓越的空间分辨率，研究年轻酒精依赖女性与正常女性之间脑灌注的差异。

方法

8名酒精依赖女性和8名对照者（年龄均为18 - 25岁）接受了单层面静息灌注加权MRI（与脑血流量成正比），扫描层面位于胼胝体上方。

结果

酒精依赖女性的前额叶和左侧顶叶区域灌注减少。

结论

此前尚未有关于年轻、身体健康的酒精依赖女性灌注减少的报道，但这与先前报道的酒精依赖中脑活动减少是一致的。