Myers Kendall P, Olsen Christopher W, Gray Gregory C
Center for Emerging Infectious Diseases, Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA.
Clin Infect Dis. 2007 Apr 15;44(8):1084-8. doi: 10.1086/512813. Epub 2007 Mar 6.
As the threat of a pandemic looms, improvement in our understanding of interspecies transmission of influenza is necessary. Using the search terms "swine," "influenza," and "human," we searched the PubMed database in April 2006 to identify publications describing symptomatic infections of humans with influenza viruses of swine origin. From these reports, we extracted data regarding demographic characteristics, epidemiological investigations, and laboratory results. We found 50 cases of apparent zoonotic swine influenza virus infection, 37 of which involved civilians and 13 of which involved military personnel, with a case-fatality rate of 14% (7 of 50 persons). Most civilian subjects (61%) reported exposure to swine. Although sporadic clinical cases of swine influenza occur in humans, the true incidence of zoonotic swine influenza virus infection is unknown. Because prior studies have shown that persons who work with swine are at increased risk of zoonotic influenza virus infection, it is prudent to include them in pandemic planning efforts.
随着大流行威胁迫在眉睫，有必要增进我们对流感跨物种传播的了解。我们使用“猪”“流感”和“人类”等检索词，于2006年4月在PubMed数据库中进行检索，以确定描述人类感染猪源流感病毒后出现症状的出版物。从这些报告中，我们提取了有关人口统计学特征、流行病学调查和实验室结果的数据。我们发现了50例明显的人畜共患猪流感病毒感染病例，其中37例涉及平民，13例涉及军事人员，病死率为14%（50人中有7人）。大多数平民受试者（61%）报告接触过猪。虽然人类中偶发猪流感临床病例，但人畜共患猪流感病毒感染的真实发病率尚不清楚。由于先前的研究表明，与猪接触的人感染人畜共患流感病毒的风险增加，因此将他们纳入大流行规划工作是明智的。
