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一种使用离子液体进行高取代吡啶三组分合成的改进方法。

An improved procedure for the three-component synthesis of highly substituted pyridines using ionic liquid.

作者信息

Ranu Brindaban C, Jana Ranjan, Sowmiah S

机构信息

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India.

出版信息

J Org Chem. 2007 Apr 13;72(8):3152-4. doi: 10.1021/jo070015g. Epub 2007 Mar 17.

DOI:10.1021/jo070015g
PMID:17367198
Abstract

A basic ionic liquid, [bmIm]OH, efficiently promotes a one-pot, three-component condensation of aldehydes, malononitrile, and thiophenols to produce highly substituted pyridines in high yields at room temperature. This reaction does not involve any hazardous organic solvent and toxic catalyst. The ionic liquid is recovered and recycled for subsequent reactions.

摘要

一种碱性离子液体[bmIm]OH能够在室温下高效地促进醛、丙二腈和硫酚的一锅三组分缩合反应，以高收率生成高度取代的吡啶。该反应不涉及任何有害有机溶剂和有毒催化剂。离子液体可回收并循环用于后续反应。

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