Yamazaki K, Saito Y, Okada F, Fujieda T, Yamashita I
J Autism Child Schizophr. 1975 Dec;5(4):323-32. doi: 10.1007/BF01540679.
The response of plasma 11-hydroxycorticosteroids (11-OHCS) to intravenous pyrogen as well as the circadian rhythm of plasma 11-OHCS levels were investigated in seven autistic children and in two children with Heller's syndrome. In autistic children, the stress response, which is acquired in an earlier stage of development, was adequately sustained. However, the circadian rhythm, which seems to appear at a later stage with the maturity of the CNS, frequently revealed abnormal patterns. Similar findings were obtained in the Heller's syndrome cases, indicating organic changes in the brain. On the basis of these results, it is postulated that in early infantile autism there exist some functional changes in the CNS that show a close correlation to the regulatory mechanism of ACTH secretion.
对7名自闭症儿童和2名海勒氏综合征患儿的血浆11 - 羟皮质类固醇（11 - OHCS）对静脉注射热原的反应以及血浆11 - OHCS水平的昼夜节律进行了研究。在自闭症儿童中，在发育早期获得的应激反应得到了充分维持。然而，似乎在中枢神经系统成熟的后期出现的昼夜节律，常常显示出异常模式。在海勒氏综合征病例中也获得了类似的结果，表明大脑存在器质性变化。基于这些结果，推测在早期婴儿自闭症中，中枢神经系统存在一些功能变化，这些变化与促肾上腺皮质激素分泌的调节机制密切相关。
