Rahman Mustafizur, Sultana Rasheda, Ahmed Giasuddin, Nahar Sharifun, Hassan Zahid M, Saiada Farjana, Podder Goutam, Faruque Abu S G, Siddique A K, Sack David A, Matthijnssens Jelle, Van Ranst Marc, Azim Tasnim
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh.
Emerg Infect Dis. 2007 Jan;13(1):18-24. doi: 10.3201/eid1301.060910.
Approximately 20,000 stool specimens from patients with diarrhea visiting 1 urban and 1 rural hospital in Bangladesh during January 2001-May 2006 were tested for group A rotavirus antigen, and 4,712 (24.0%) were positive. G and P genotyping was performed on a subset of 10% of the positive samples (n = 471). During the 2001-2005 rotavirus seasons, G1P[8] (36.4%) and G9P[8] (27.7%) were the dominant strains, but G2[4] and G12P[6] were present in 15.4% and 3.1% of the rotavirus-positive patients, respectively. During the 2005-06 rotavirus season, G2P[4] (43.2%) appeared as the most prevalent strain, and G12P[6] became a more prevalent strain (11.1%) during this season. Because recently licensed rotavirus vaccines include only the P[8] specificity, it is unknown how the vaccines will perform in settings where non-P[8] types are prevalent.
2001年1月至2006年5月期间，从孟加拉国一家城市医院和一家农村医院腹泻患者中采集了约20,000份粪便标本，检测A组轮状病毒抗原，其中4,712份（24.0%）呈阳性。对10%的阳性样本（n = 471）进行了G和P基因分型。在2001 - 2005年轮状病毒流行季节，G1P[8]（36.4%）和G9P[8]（27.7%）是主要毒株，但G2[4]和G12P[6]分别在15.4%和3.1%的轮状病毒阳性患者中出现。在2005 - 2006年轮状病毒流行季节，G2P[4]（43.2%）成为最常见的毒株，G12P[6]在该季节也成为更常见的毒株（11.1%）。由于最近获批的轮状病毒疫苗仅包含P[8]特异性，因此尚不清楚这些疫苗在非P[8]型流行的环境中效果如何。
