单次服用24毫克丁丙诺啡用于海洛因脱毒：5例住院患者的开放标签研究
Single dose of 24 milligrams of buprenorphine for heroin detoxification: an open-label study of five inpatients.
作者信息
Ang-Lee Kathleen, Oreskovich Michael R, Saxon Andrew J, Jaffe Craig, Meredith Charles, Ellis Mei Ling K, Malte Carol A, Knox Patricia C
机构信息
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington 98195-6560, USA.
出版信息
J Psychoactive Drugs. 2006 Dec;38(4):505-12. doi: 10.1080/02791072.2006.10400589.
Previous studies indicate that buprenorphine has efficacy in medically supervised opioid withdrawal, but the optimal dosing for maximum tolerability and ease of administration remains undetermined. Five heroin-dependent individuals entered this open-label study of inpatient detoxification with a single 24 mg dose of buprenorphine. The mean Clinical Opiate Withdrawal Scale (COWS) score prior to buprenorphine administration was 17.6 (SD = 3.36). COWS scores declined significantly thereafter. There was one episode of precipitated withdrawal that resolved within four hours. Use of ancillary medications was minimal. This study suggests that a single high dose of buprenorphine can be used safely and effectively for inpatient detoxification.
先前的研究表明，丁丙诺啡在医学监督下的阿片类药物戒断中有疗效，但关于最大耐受性和给药便利性的最佳剂量仍未确定。五名海洛因依赖者进入了这项单剂量24毫克丁丙诺啡住院戒毒的开放标签研究。给药前临床阿片戒断量表（COWS）平均得分为17.6（标准差=3.36）。此后COWS得分显著下降。有一次急性戒断发作在四小时内得到缓解。辅助药物的使用极少。这项研究表明，单次高剂量丁丙诺啡可安全有效地用于住院戒毒。
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