Kao C H, Tsou C T, Wang S J, Yeh S H
Department of Nuclear Medicine and Endocrinology, Taichung Veterans General Hospital, Taiwan, Republic of China.
Nucl Med Commun. 1993 Oct;14(10):868-72. doi: 10.1097/00006231-199310000-00006.
Twenty-nine patients (24 males, 5 females; aged 62.8 +/- 10.1 years) with noninsulin-dependent diabetes mellitus (NIDDM) without gallstones and impaired liver function were included in our study. The patients were categorized by blood sugar control and disease duration. Twelve normal controls (10 males, 2 females; aged 62.8 +/- 12.4 years) were also studied for comparison. The gallbladder filling fraction (FF) and ejection fraction (EF) were calculated following the method of Krishnamurthy et al. The results showed no significant difference (P > 0.5) between (1) NIDDM and normal controls in FF (69.1 +/- 29.4 versus 67.5 +/- 24.0%) and EF (45.0 +/- 23.5 versus 54.8 +/- 10.0%) by a t-test, (2) good and poor blood sugar control in FF (64.9 +/- 30.9 versus 73.7 +/- 26.4%) and EF (42.0 +/- 25.4 versus 54.8 +/- 10.0%) by a Mann-Whitney U test, (3) long and short disease durations in FF (70.9 +/- 29.7 versus 67.9 +/- 28.7%) and EF (37.9 +/- 20.7 versus 50.0 +/- 24.1%) by a Mann-Whitney U test. In conclusion, the results challenge some previous reports and warrant further research.
本研究纳入了29例无胆结石且肝功能正常的非胰岛素依赖型糖尿病（NIDDM）患者（24例男性，5例女性；年龄62.8±10.1岁）。根据血糖控制情况和病程对患者进行分类。还研究了12名正常对照者（10例男性，2例女性；年龄62.8±12.4岁）以作比较。按照Krishnamurthy等人的方法计算胆囊充盈分数（FF）和射血分数（EF）。结果显示：（1）通过t检验，NIDDM患者与正常对照者在FF（69.1±29.4对67.5±24.0%）和EF（45.0±23.5对54.8±10.0%）方面无显著差异（P>0.5）；（2）通过Mann-Whitney U检验，血糖控制良好与不佳者在FF（64.9±30.9对73.7±26.4%）和EF（42.0±25.4对54.8±10.0%）方面无显著差异；（3）通过Mann-Whitney U检验，病程长与短者在FF（70.9±29.7对67.9±28.7%）和EF（37.9±20.7对50.0±24.1%）方面无显著差异。总之，这些结果对之前的一些报告提出了质疑，值得进一步研究。
