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腺苷酸环化酶激活剂福斯高林及其无活性衍生物1,9-二脱氧福斯高林对昆虫细胞色素P-450依赖性类固醇羟化酶活性的影响。

Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity.

作者信息

Keogh D P, Mitchell M J, Crooks J R, Smith S L

机构信息

Department of Biological Sciences, Bowling Green State University, Ohio 43403-0212.

出版信息

Experientia. 1992 Jan 15;48(1):39-41. doi: 10.1007/BF01923603.

Abstract

The adenylate cyclase activator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin were found to inhibit in a dose-dependent fashion the ecdysone 20-monooxygenase activity associated with wandering stage larvae of Drosophila melanogaster and fat body and midgut from last instar larvae of the tobacco hornworm, Manduca sexta. The concentrations of these labdane diterpenes required to elicit a 50% inhibition of the cytochrome P-450 dependent steroid hydroxylase activity in the insect tissues ranged from approximately 5 x 10(-6) to 5 x 10(-4) M.

摘要

已发现腺苷酸环化酶激活剂福司可林及其药理惰性衍生物1,9-二脱氧福司可林能以剂量依赖方式抑制与黑腹果蝇末龄幼虫的化蛹前期幼虫以及烟草天蛾末龄幼虫的脂肪体和中肠相关的蜕皮激素20-单加氧酶活性。在昆虫组织中引起细胞色素P-450依赖性类固醇羟化酶活性50%抑制所需的这些半日花烷二萜的浓度范围约为5×10⁻⁶至5×10⁻⁴M。

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