• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

几丁质合成酶抑制剂白花丹素及其2-去甲基衍生物胡桃醌对昆虫蜕皮激素20-单加氧酶活性的影响。

Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity.

作者信息

Mitchell M J, Smith S L

机构信息

Department of Biological Sciences, Bowling Green State University, Ohio 43403.

出版信息

Experientia. 1988 Dec 1;44(11-12):990-1. doi: 10.1007/BF01939896.

DOI:10.1007/BF01939896
PMID:2973991
Abstract

The chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone were found to inhibit in a dose-response fashion the cytochrome P-450 dependent ecdysone 20-monooxygenase activity associated with adult female Aedes aegypti, wandering stage larvae of Drosophila melanogaster, and fat body and midgut from last instar larvae of Manduca sexta. The concentration of these naphthoquinones required to elicit a 50% inhibition of the steroid hydroxylase activity in all the insects was approximately 1 x 10(-4) M.

摘要

已发现几丁质合成酶抑制剂白花丹素及其2-去甲基衍生物胡桃醌能以剂量反应方式抑制与成年雌性埃及伊蚊、黑腹果蝇的漫游期幼虫以及烟草天蛾末龄幼虫的脂肪体和中肠相关的细胞色素P-450依赖性蜕皮激素20-单加氧酶活性。在所有昆虫中引起甾体羟化酶活性50%抑制所需的这些萘醌浓度约为1×10⁻⁴ M。

相似文献

1
Effects of the chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone on insect ecdysone 20-monooxygenase activity.几丁质合成酶抑制剂白花丹素及其2-去甲基衍生物胡桃醌对昆虫蜕皮激素20-单加氧酶活性的影响。
Experientia. 1988 Dec 1;44(11-12):990-1. doi: 10.1007/BF01939896.
2
Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity.化合物2-甲氧基萘醌、2-丙氧基萘醌和2-异丙氧基萘醌对蜕皮激素20-单加氧酶活性的影响。
Arch Insect Biochem Physiol. 2007 Sep;66(1):45-52. doi: 10.1002/arch.20196.
3
Effects of azadirachtin on insect cytochrome P-450 dependent ecdysone 20-monooxygenase activity.印楝素对昆虫细胞色素P-450依赖性蜕皮激素20-单加氧酶活性的影响。
Biochem Biophys Res Commun. 1988 Jul 29;154(2):559-63. doi: 10.1016/0006-291x(88)90176-3.
4
Effects of plant flavonoids and other allelochemicals on insect cytochrome P-450 dependent steroid hydroxylase activity.植物类黄酮及其他化感物质对昆虫细胞色素P-450依赖性甾体羟化酶活性的影响。
Insect Biochem Mol Biol. 1993 Jan;23(1):65-71. doi: 10.1016/0965-1748(93)90083-5.
5
Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity.腺苷酸环化酶激活剂福斯高林及其无活性衍生物1,9-二脱氧福斯高林对昆虫细胞色素P-450依赖性类固醇羟化酶活性的影响。
Experientia. 1992 Jan 15;48(1):39-41. doi: 10.1007/BF01923603.
6
Effects of the neem tree compounds azadirachtin, salannin, nimbin, and 6-desacetylnimbin on ecdysone 20-monooxygenase activity.印楝树化合物印楝素、萨兰宁、尼姆宾和6-脱乙酰基尼姆宾对蜕皮激素20-单加氧酶活性的影响。
Arch Insect Biochem Physiol. 1997;35(1-2):199-209. doi: 10.1002/(SICI)1520-6327(1997)35:1/2<199::AID-ARCH18>3.0.CO;2-6.
7
Regulation of cytochrome P-450 dependent steroid hydroxylase activity in Manduca sexta: effects of the ecdysone agonist RH 5849 on ecdysone 20-monooxygenase activity.烟草天蛾中细胞色素P-450依赖性甾体羟化酶活性的调节：蜕皮激素激动剂RH 5849对蜕皮激素20-单加氧酶活性的影响。
Biochem Biophys Res Commun. 1991 Apr 15;176(1):522-7. doi: 10.1016/0006-291x(91)90956-8.
8
Ecdysone 20-monooxygenase: characterization of an insect cytochrome p-450 dependent steroid hydroxylase.蜕皮激素20-单加氧酶：一种昆虫细胞色素P-450依赖性甾体羟化酶的特性
Mol Cell Endocrinol. 1979 Sep;15(3):111-33. doi: 10.1016/0303-7207(79)90033-9.
9
Ecdysone 20-monooxygenase activity during larval-pupal development of Manduca sexta.烟草天蛾幼虫-蛹发育过程中的蜕皮激素20-单加氧酶活性
Mol Cell Endocrinol. 1983 Aug;31(2-3):227-51. doi: 10.1016/0303-7207(83)90151-x.
10
Regulation of cytochrome P-450 dependent steroid hydroxylase activity in Manduca sexta: evidence for the involvement of a neuroendocrine-endocrine axis during larval-pupal development.烟草天蛾中细胞色素P-450依赖性类固醇羟化酶活性的调节：幼虫-蛹发育过程中神经内分泌-内分泌轴参与的证据。
Biochem Biophys Res Commun. 1989 Nov 30;165(1):442-8. doi: 10.1016/0006-291x(89)91090-5.

引用本文的文献

1
Plumbagin, a Potent Naphthoquinone from Plants with Growth Inhibiting and Larvicidal Activities.白花丹素，一种来自植物的具有生长抑制和杀幼虫活性的萘醌。
Molecules. 2021 Feb 5;26(4):825. doi: 10.3390/molecules26040825.
2
Function of PIN1 in Cancer Development and Its Inhibitors as Cancer Therapeutics.PIN1在癌症发展中的作用及其抑制剂作为癌症治疗药物的研究
Front Cell Dev Biol. 2020 Mar 17;8:120. doi: 10.3389/fcell.2020.00120. eCollection 2020.
3
…Fell Upas Sits, the Hydra-Tree of Death , or the Phytotoxicity of Trees.…跌落在“死亡之树”，九头蛇树，或者是树木的植物毒性上。

本文引用的文献

1
Ecdysone 20-monooxygenase activity during larval-pupal development of Manduca sexta.烟草天蛾幼虫-蛹发育过程中的蜕皮激素20-单加氧酶活性
Mol Cell Endocrinol. 1983 Aug;31(2-3):227-51. doi: 10.1016/0303-7207(83)90151-x.
2
Ecdysone-mediated stimulation of DOPA decarboxylase activity and its relationship to ovarian development in Aedes aegypti.蜕皮激素介导的埃及伊蚊多巴脱羧酶活性刺激及其与卵巢发育的关系。
J Cell Biol. 1974 May;61(2):454-65. doi: 10.1083/jcb.61.2.454.
3
Chemosensory mechanism in Periplaneta americana: electroantennogram comparisons of certain quinone feeding inhibitors.
Molecules. 2019 Apr 25;24(8):1636. doi: 10.3390/molecules24081636.
4
Biosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plants.园艺植物产生的特定 1,4-萘醌天然产物的生物合成和分子作用。
Hortic Res. 2016 Sep 21;3:16046. doi: 10.1038/hortres.2016.46. eCollection 2016.
5
Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths.胡桃醌（5-羟基-1,4-萘醌）和相关萘醌对天蚕蛾科昆虫的毒性差异。
J Chem Ecol. 1994 Jul;20(7):1631-41. doi: 10.1007/BF02059885.
6
Compounds active against cell walls of medically important fungi.对医学上重要真菌的细胞壁具有活性的化合物。
Clin Microbiol Rev. 1993 Jan;6(1):1-21. doi: 10.1128/CMR.6.1.1.
J Insect Physiol. 1974 Sep;20(9):1687-96. doi: 10.1016/0022-1910(74)90198-x.
4
Effects of feeding-inhibitory quinones on the nervous system of Periplaneta.
Experientia. 1972 Jan 15;28(1):31-2. doi: 10.1007/BF01928245.
5
The effect of alpha-ecdysone and phenobarbital on the alpha-ecdysone 20-monooxygenase of house fly larva.α-蜕皮激素和苯巴比妥对家蝇幼虫α-蜕皮激素20-单加氧酶的影响。
Biochem Biophys Res Commun. 1987 Nov 13;148(3):1075-80. doi: 10.1016/s0006-291x(87)80241-3.
6
The mechanism of C-20 hydroxylation of alpha-ecdysone in the desert locust, Schistocerca gregaria.沙漠蝗（Schistocerca gregaria）中α-蜕皮激素C-20羟基化的机制。
Biochem J. 1977 Dec 15;168(3):513-20. doi: 10.1042/bj1680513.
7
Ecdysterone biosynthesis: a microsomal cytochrome-P-450-linked ecdysone 20-monooxygenase from tissues of the African migratory locust.蜕皮甾酮生物合成：来自非洲迁徙蝗虫组织的一种与微粒体细胞色素P-450相关的蜕皮激素20-单加氧酶。
Eur J Biochem. 1978 Jul 17;88(1):37-47. doi: 10.1111/j.1432-1033.1978.tb12420.x.