Mitchell M J, Smith S L
Department of Biological Sciences, Bowling Green State University, Ohio 43403.
Experientia. 1988 Dec 1;44(11-12):990-1. doi: 10.1007/BF01939896.
The chitin synthetase inhibitor plumbagin and its 2-demethyl derivative juglone were found to inhibit in a dose-response fashion the cytochrome P-450 dependent ecdysone 20-monooxygenase activity associated with adult female Aedes aegypti, wandering stage larvae of Drosophila melanogaster, and fat body and midgut from last instar larvae of Manduca sexta. The concentration of these naphthoquinones required to elicit a 50% inhibition of the steroid hydroxylase activity in all the insects was approximately 1 x 10(-4) M.
已发现几丁质合成酶抑制剂白花丹素及其2-去甲基衍生物胡桃醌能以剂量反应方式抑制与成年雌性埃及伊蚊、黑腹果蝇的漫游期幼虫以及烟草天蛾末龄幼虫的脂肪体和中肠相关的细胞色素P-450依赖性蜕皮激素20-单加氧酶活性。在所有昆虫中引起甾体羟化酶活性50%抑制所需的这些萘醌浓度约为1×10⁻⁴ M。
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