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Proopiomelanocortin expression in the skin during induced hair growth in mice.

作者信息

Slominski A, Paus R, Mazurkiewicz J

机构信息

Department of Immunology and Microbiology, Albany Medical College, New York 12202.

出版信息

Experientia. 1992 Jan 15;48(1):50-4. doi: 10.1007/BF01923606.

DOI:10.1007/BF01923606
PMID:1737578
Abstract

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30-33 kDa recognized by anti beta-endorphin in late but not early anagen or telogen skin. By immunocytochemistry, beta-endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.

摘要

相似文献

1
Proopiomelanocortin expression in the skin during induced hair growth in mice.
Experientia. 1992 Jan 15;48(1):50-4. doi: 10.1007/BF01923606.
2
Pro-opiomelanocortin expression and potential function of pro-opiomelanocortin products during induced hair growth in mice.小鼠诱导毛发生长过程中阿片促黑皮质素原的表达及阿片促黑皮质素原产物的潜在功能
Ann N Y Acad Sci. 1991 Dec 26;642:459-61. doi: 10.1111/j.1749-6632.1991.tb24417.x.
3
Identification and measurement of beta-endorphin levels in the skin during induced hair growth in mice.小鼠毛发诱导生长过程中皮肤中β-内啡肽水平的鉴定与测量。
Biochim Biophys Acta. 1997 Aug 29;1336(2):315-22. doi: 10.1016/s0304-4165(97)00046-9.
4
The skin POMC system (SPS). Leads and lessons from the hair follicle.皮肤促黑素细胞激素原系统（SPS）。毛囊的线索与启示。
Ann N Y Acad Sci. 1999 Oct 20;885:350-63. doi: 10.1111/j.1749-6632.1999.tb08690.x.
5
Production of POMC, CRH-R1, MC1, and MC2 receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin.C57BL/6小鼠皮肤中阿黑皮素原、促肾上腺皮质激素释放激素受体1、黑素皮质素受体1和黑素皮质素受体2 mRNA的产生以及酪氨酸酶基因表达与毛发周期和地塞米松治疗的关系
J Invest Dermatol. 1997 Feb;108(2):160-5. doi: 10.1111/1523-1747.ep12332925.
6
Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin.阿片促黑激素皮质素原（POMC）及其衍生肽在小鼠皮肤中的时空表达、分布及加工过程
J Histochem Cytochem. 2000 Jul;48(7):905-14. doi: 10.1177/002215540004800703.
7
An immunocytochemical approach to the study of beta-endorphin production in human keratinocytes using confocal microscopy.一种利用共聚焦显微镜研究人角质形成细胞中β-内啡肽产生的免疫细胞化学方法。
Ann N Y Acad Sci. 1999 Oct 20;885:85-99. doi: 10.1111/j.1749-6632.1999.tb08667.x.
8
Proopiomelanocortin, its derived peptides, and the skin.阿黑皮素原、其衍生肽与皮肤。
J Invest Dermatol. 1996 Jan;106(1):3-10. doi: 10.1111/1523-1747.ep12326950.
9
The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin.促肾上腺皮质激素原（POMC）和促肾上腺皮质激素释放激素受体（CRH-R）基因在小鼠皮肤中的表达。
Biochim Biophys Acta. 1996 Mar 15;1289(2):247-51. doi: 10.1016/0304-4165(95)00159-x.
10
On the potential role of proopiomelanocortin in skin physiology and pathology.论阿片促黑皮质素原在皮肤生理与病理中的潜在作用。
Mol Cell Endocrinol. 1993 May;93(1):C1-6. doi: 10.1016/0303-7207(93)90131-3.

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本文引用的文献

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Growth of the hair.毛发的生长。
Physiol Rev. 1954 Jan;34(1):113-26. doi: 10.1152/physrev.1954.34.1.113.
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The mouse genome contains two nonallelic pro-opiomelanocortin genes.小鼠基因组包含两个非等位的阿黑皮素原基因。
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The distribution of forms of adrenocorticotropin and beta-endorphin in normal, tumorous, and autopsy human anterior pituiary tissue: virtual absence of 13K adrenocorticotropin.促肾上腺皮质激素和β-内啡肽在正常、肿瘤及尸检人类垂体前叶组织中的分布形式：13K促肾上腺皮质激素几乎不存在。
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Genes Immun. 2020 May;21(3):150-168. doi: 10.1038/s41435-020-0096-6. Epub 2020 Mar 23.
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Neuroendocrine Aspects of Skin Aging.皮肤衰老的神经内分泌方面。
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Immune Privilege Collapse and Alopecia Development: Is Stress a Factor.免疫赦免崩溃与脱发的发生：压力是一个因素吗？
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Neuroendocrinology of the skin.皮肤的神经内分泌学。
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Melanin production through novel processing of proopiomelanocortin in the extracellular compartment of the auricular skin of C57BL/6 mice after UV-irradiation.紫外线照射后C57BL/6小鼠耳廓皮肤细胞外区室中通过阿黑皮素原的新型加工产生黑色素。
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9
UVB Activates Hypothalamic-Pituitary-Adrenal Axis in C57BL/6 Mice.紫外线B激活C57BL/6小鼠的下丘脑-垂体-肾上腺轴。
J Invest Dermatol. 2015 Jun;135(6):1638-1648. doi: 10.1038/jid.2014.450. Epub 2014 Oct 15.
10
Commentary on the practical guide for the study of sebaceous glands.皮脂腺研究实用指南述评。
Exp Dermatol. 2013 Oct;22(10):629-30. doi: 10.1111/exd.12221.
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4
Proopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues.阿黑皮素原在垂体、中枢神经系统和外周组织中的加工过程。
Endocr Rev. 1988 Feb;9(1):159-79. doi: 10.1210/edrv-9-1-159.
5
Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome.阿片促黑皮质素原基因在许多正常人体组织以及与异位促肾上腺皮质激素综合征无关的肿瘤中表达。
Mol Endocrinol. 1988 Sep;2(9):862-70. doi: 10.1210/mend-2-9-862.
6
Hormonal regulation of POMC gene expression.促肾上腺皮质激素原基因表达的激素调节。
Annu Rev Physiol. 1989;51:715-26. doi: 10.1146/annurev.ph.51.030189.003435.
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Control and function of sebaceous glands.皮脂腺的调控与功能。
Physiol Rev. 1989 Apr;69(2):383-416. doi: 10.1152/physrev.1989.69.2.383.
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Alpha-melanocyte stimulating hormone modulates contact hypersensitivity responsiveness in C57/BL6 mice.α-黑素细胞刺激素调节C57/BL6小鼠的接触性超敏反应性。
J Invest Dermatol. 1989 Oct;93(4):511-7. doi: 10.1111/1523-1747.ep12284064.
9
Telogen skin contains an inhibitor of hair growth.休止期皮肤含有头发生长抑制剂。
Br J Dermatol. 1990 Jun;122(6):777-84. doi: 10.1111/j.1365-2133.1990.tb06266.x.
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Beta-endorphin-like and alpha-MSH-like immunoreactivities in human milk.人乳中的β-内啡肽样和α-促黑素细胞激素样免疫反应性
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