Lee Li-Po, Dai Chia-Yen, Chuang Wan-Long, Chang Wen-Yu, Hou Nei-Jen, Hsieh Ming-Yen, Lin Zu-Yau, Chen Shinn-Cherng, Hsieh Ming-Yuh, Wang Liang-Yen, Chen Tong-Jong, Yu Ming-Lung
Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Chung-Ho Memorial Hospital, Taiwan.
J Gastroenterol Hepatol. 2007 Apr;22(4):515-7. doi: 10.1111/j.1440-1746.2006.04547.x.
The aim of the present study was to compare the histological characteristics of livers between chronic hepatitis C (CHC) patients with and without hepatitis B virus (HBV) coinfection.
A total of 336 CHC patients (male/female: 204/132, mean age: 46.1 +/- 11.7 years) were enrolled in the study; 32 patients (9.8%) were positive for hepatitis B surface antigen (HBsAg). The histological characteristics of livers were described according to the Knodell and Scheuer scoring system.
The proportion of non-intralobular necrosis (score 0) was significantly lower and the mean intralobular necrosis score was higher among CHC patients with HBV coinfection than those without coinfection (43.8% vs 64.5%; 0.84 +/- 1.05 vs 0.53 +/- 0.89). The epidemiological and virological parameters, and other histological scores (periportal necrosis, portal inflammation, total necroinflammation and fibrosis) were not significantly different between these two groups.
Chronic hepatitis C patients with HBV coinfection tend to have more severe intralobular necrosis than those with isolated HCV infection.
本研究的目的是比较合并和未合并乙型肝炎病毒（HBV）感染的慢性丙型肝炎（CHC）患者肝脏的组织学特征。
共有336例CHC患者（男/女：204/132，平均年龄：46.1±11.7岁）纳入本研究；32例患者（9.8%）乙型肝炎表面抗原（HBsAg）呈阳性。根据Knodell和Scheuer评分系统描述肝脏的组织学特征。
合并HBV感染的CHC患者非小叶内坏死（评分为0）的比例显著低于未合并感染的患者，且小叶内坏死平均评分更高（43.8%对64.5%；0.84±1.05对0.53±0.89）。这两组之间的流行病学和病毒学参数以及其他组织学评分（汇管区周围坏死、门管区炎症、总坏死炎症和纤维化）无显著差异。
合并HBV感染的慢性丙型肝炎患者比单纯感染HCV的患者往往有更严重的小叶内坏死。
Zotero 插件