Pan Y, Jackson R T
Department of Nutrition and Food Science, University of Maryland, College Park, MD, USA.
Epidemiol Infect. 2008 Mar;136(3):421-31. doi: 10.1017/S095026880700831X. Epub 2007 Mar 22.
This study examined the ethnic difference in the association between increased serum ferritin (SF) (>300 microg/l) and acute inflammation (AI) (C-reactive protein > or = 1.0 mg/dl) between black and white males aged > or = 20 years. Using data from the third National Health and Nutrition Examination Survey (NHANES III), we determined the risk for having elevated SF in black males (n=164) and white males (n=325) with AI present as well as black males (n=1731) and white males (n=2877) with AI absent. Black subjects with AI present were 1.71 times (95% CI 1.18-2.49), and 1.87 times (95% CI 1.46-2.40) more likely to have increased SF than AI absent blacks and AI present whites, respectively. Furthermore, with AI present, every increment of C-reactive protein, white blood cell count, serum albumin, lymphocyte count and platelet count was associated with higher odds of having elevations in SF in blacks than whites. Regardless of AI status, blacks were more likely to have elevations in SF than whites, and the prevalence of elevated SF was significantly higher in blacks than whites. This finding suggested that black males may respond to inflammation with a more aggressive rise in SF compared to white males. Future research is needed to investigate the underlying mechanisms.
本研究调查了年龄≥20岁的黑人和白人男性中，血清铁蛋白（SF）升高（>300μg/l）与急性炎症（AI）（C反应蛋白≥1.0mg/dl）之间关联的种族差异。利用第三次全国健康和营养检查调查（NHANES III）的数据，我们确定了存在AI的黑人男性（n = 164）和白人男性（n = 325）以及不存在AI的黑人男性（n = 1731）和白人男性（n = 2877）中SF升高的风险。存在AI的黑人受试者SF升高的可能性分别比不存在AI的黑人及存在AI的白人高1.71倍（95%CI 1.18 - 2.49）和1.87倍（95%CI 1.46 - 2.40）。此外，在存在AI的情况下，C反应蛋白、白细胞计数、血清白蛋白、淋巴细胞计数和血小板计数的每一次增加，与黑人相比白人SF升高的几率更高相关。无论AI状态如何，黑人比白人更有可能出现SF升高，且黑人中SF升高的患病率显著高于白人。这一发现表明，与白人男性相比，黑人男性可能对炎症做出更强烈的SF升高反应。需要进一步的研究来调查其潜在机制。
