Simhan Hyagriv N, Krohn Marijane A, Roberts James M, Zeevi Adriana, Caritis Steve N
University of Pittsburgh School of Medicine, Department of Obstetrics, Magee-Womens Research Institute, Pittsburgh, Pa., USA.
Am J Obstet Gynecol. 2003 Oct;189(4):915-8. doi: 10.1067/s0002-9378(03)00843-3.
We assessed the relationship between interleukin-6 (IL-6) promoter -174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (P<.001)
The IL-6 promoter -174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.
我们评估了白细胞介素-6（IL-6）启动子-174多态性与孕周小于34周的自发性早产（sPTB）之间的关系，以及多态性状态与种族的关系。
采用聚合酶链反应评估156名足月自然分娩的对照组和51名孕周小于34周的sPTB受试者的DNA。
在156名对照组中，C/C变异型存在于30例（19.2%）。在51名受试者中，C/C变异型存在于2例（6.3%）（比值比0.17，95%可信区间0.04 - 0.74）。在白人女性中，C/C变异型存在于30例（27.2%）对照组，但仅2例（5.2%）病例。没有非裔美国女性携带C/C变异型。种族差异具有统计学意义（P <.001）。
IL-6启动子-174等位基因变异型C/C在孕周小于34周的sPTB女性中显著较少见。这种多态性的等位基因变异分布存在显著的种族差异。
