Pinsk Vared, Lemberg Daniel A, Grewal Karan, Barker Collin C, Schreiber Richard A, Jacobson Kevan
Division of Gastroenterology, B.C. Children's Hospital, Vancouver, British Columbia, Canada.
Am J Gastroenterol. 2007 May;102(5):1077-83. doi: 10.1111/j.1572-0241.2007.01124.x. Epub 2007 Mar 22.
Geographical differences, population migration, and changing demographics suggest an environmental role in prevalence, modulation, and phenotypic expression of inflammatory bowel disease (IBD).
To determine the incidence of IBD and disease subtype in the pediatric South Asian population in British Columbia (BC) compared with non-South Asian IBD patients in the same geographic area.
Chart review with data collected for all patients <or=16 yr of age diagnosed with IBD at B.C. Children's hospital, January 1985 to June 2005. Age, gender, family history, duration of symptoms, type, and extent of disease were extracted. Identified South Asian subjects were prospectively interviewed.
Seventy-five South Asian patients were diagnosed with IBD, 48% Crohn's disease (CD), 33.3% ulcerative colitis (UC), and 18.7% with indeterminate colitis (IC), in contrast to 71%, 18.8%, and 10.2%, respectively, in the non-South Asian population. The incidence rate for South Asian IBD patients, for the period 1996-2001 was 15.19/10(5) (6.41/10(5) for CD, 6.70/10(5) for UC, and 2.08/10(5) for IC) compared with 5.19/10(5) for the non-South Asian IBD group (3.69/10(5), 0.96/10(5), and 0.54/10(5), respectively). The South Asian male/female ratio was significantly different from that observed for the rest of the population.
These data suggest a significantly higher incidence of IBD in the South Asian pediatric population compared with the rest of the BC pediatric population, with a different pattern of phenotypic expression, a male predominance, and more extensive colonic disease. These data suggest a potential effect of migration, and environmental and lifestyle change on the incidence of IBD and disease subtype.
地理差异、人口迁移和不断变化的人口结构表明环境因素在炎症性肠病（IBD）的患病率、调节和表型表达中发挥作用。
确定不列颠哥伦比亚省（BC）南亚裔儿童人群中IBD及疾病亚型的发病率，并与同一地理区域的非南亚裔IBD患者进行比较。
回顾1985年1月至2005年6月在BC儿童医院确诊为IBD的所有年龄≤16岁患者的病历资料。提取年龄、性别、家族史、症状持续时间、疾病类型和范围等信息。对确诊的南亚裔受试者进行前瞻性访谈。
75名南亚裔患者被诊断为IBD，其中48%为克罗恩病（CD），33.3%为溃疡性结肠炎（UC），18.7%为不确定性结肠炎（IC）；相比之下，非南亚裔人群中这三种疾病的比例分别为71%、18.8%和10.2%。1996 - 2001年期间，南亚裔IBD患者的发病率为15.19/10⁵（CD为6.41/10⁵，UC为6.70/10⁵，IC为2.08/10⁵），而非南亚裔IBD组的发病率为5.19/10⁵（分别为3.69/10⁵、0.96/10⁵和0.54/10⁵）。南亚裔的男女比例与其他人群显著不同。
这些数据表明，与BC省其他儿童人群相比，南亚裔儿童人群中IBD的发病率显著更高，具有不同的表型表达模式、男性占优势以及更广泛的结肠疾病。这些数据表明迁移、环境和生活方式的改变对IBD发病率和疾病亚型可能产生影响。
