多巴胺对人体视网膜和脉络膜血流参数的影响。
Effects of dopamine on retinal and choroidal blood flow parameters in humans.
作者信息
Huemer Karl-Heinz, Zawinka Claudia, Garhöfer Gerhard, Golestani Elisabeth, Litschauer Brigitte, Dorner Guido T, Schmetterer Leopold
机构信息
Department of Clinical Pharmacology, Medical University of Vienna, Vienna A-1090, Austria.
出版信息
Br J Ophthalmol. 2007 Sep;91(9):1194-8. doi: 10.1136/bjo.2006.113399. Epub 2007 Mar 23.
AIM
To investigate the effect of dopamine on retinal and choroidal blood flow in humans.
METHODS
We investigated the effect of two doses of intravenous dopamine (5 and 10 microg/kg/min) via a randomised double-masked crossover study in 12 healthy subjects chosen from a total of 16. Blood flow parameters in retina, optic nerve head and choroid were assessed with bi-directional laser Doppler velocimetry, laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively.
RESULTS
Intravenous dopamine dose-dependently increased retinal blood cell velocity and fundus pulsation amplitude (p<0.001). At the highest administered dose red blood cell velocity in retinal vessels increased by 37% and fundus pulsation amplitude by 24%. By contrast, optic nerve head blood flow did not change with dopamine administration.
CONCLUSIONS
Our data indicate that dopamine has a pronounced enhancing effect on the retinal perfusion in humans. Further studies are required to establish the exact role of dopamine in the regulation of choroidal and optic nerve head blood flow.
目的
研究多巴胺对人体视网膜和脉络膜血流的影响。
方法
我们通过随机双盲交叉研究，对从16名健康受试者中选取的12名进行了研究，给予两剂静脉注射多巴胺（5和10微克/千克/分钟）。分别采用双向激光多普勒测速仪、激光多普勒血流仪和眼底搏动幅度激光干涉测量法评估视网膜、视神经乳头和脉络膜的血流参数。
结果
静脉注射多巴胺剂量依赖性地增加视网膜血细胞速度和眼底搏动幅度（p<0.001）。在最高给药剂量下，视网膜血管中的红细胞速度增加了37%，眼底搏动幅度增加了24%。相比之下，视神经乳头血流在给予多巴胺后没有变化。
结论
我们的数据表明多巴胺对人体视网膜灌注有显著的增强作用。需要进一步研究以确定多巴胺在脉络膜和视神经乳头血流调节中的确切作用。
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