Durmaz Engin Ceren, Akdemir Mehmet Orcun
Department of Ophthalmology, Karadeniz Eregli State Hospital, Zonguldak, Turkey.
Department of Ophthalmology, Bulent Ecevit University School of Medicine, Zonguldak, Turkey.
GMS Ophthalmol Cases. 2023 Jul 12;13:Doc13. doi: 10.3205/oc000221. eCollection 2023.
Central serous chorioretinopathy (CSCR) is a chorioretinal disease that is characterized by central vision loss and is usually seen in middle-aged males. It has been associated with the use of various drugs, including corticosteroids and phosphodiesterase inhibitors. We present the case of a 36-year-old male who developed CSCR after a few weeks of irregular use of quetiapine for his sleep problems. The clinical findings of the patient improved shortly after he stopped using the drug, and at the end of the two-month period complete recovery was observed. Quetiapine is an atypical antipsychotic that exerts its effects on dopamine and serotonin receptors. There are studies showing that these neurotransmitters may play a role in the control of choroidal vascular permeability, which is the underlying cause of CSCR. Therefore, we believe that quetiapine may have a causal relationship with CSCR. To our knowledge, this is the first case report documenting full recovery from quetiapine associated CSCR.
中心性浆液性脉络膜视网膜病变（CSCR）是一种脉络膜视网膜疾病，其特征为中心视力丧失，常见于中年男性。它与多种药物的使用有关，包括皮质类固醇和磷酸二酯酶抑制剂。我们报告一例36岁男性病例，该患者因睡眠问题不规则服用喹硫平数周后发生CSCR。患者停用该药物后不久，临床症状改善，在两个月结束时观察到完全恢复。喹硫平是一种非典型抗精神病药物，作用于多巴胺和5-羟色胺受体。有研究表明，这些神经递质可能在脉络膜血管通透性的控制中起作用，而脉络膜血管通透性是CSCR的根本病因。因此，我们认为喹硫平可能与CSCR存在因果关系。据我们所知，这是第一例记录喹硫平相关性CSCR完全恢复的病例报告。
