Nagasawa H, Wada M, Arawaka S, Kawanami T, Kurita K, Daimon M, Adachi M, Hosoya T, Emi M, Muramatsu M, Kato T
Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata, Japan.
Eur J Neurol. 2007 Apr;14(4):428-34. doi: 10.1111/j.1468-1331.2007.01700.x.
The objective of the present study was to examine the association between a polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene and lacunar infarcts of the brain. We conducted a population-based, cross-sectional study on residents from two age groups (61- and 72-year olds). A total of 376 subjects participated in the study, which included brain magnetic resonance image and genetic analysis of the ALDH2 gene. Of the 61- and 72-year-old subjects, 46.4% and 64.3%, respectively, had one or more lacunar infarcts. The average number of infarcts also increased from 2.0 to 2.8 in men and from 2.3 to 3.5 in women. No significant association between the ALDH2 genotype and the presence of lacunar infarction (> or =1) was found. However, in subjects with lacunar infarction, the genotype of ALDH2 *1/*1 was associated with a larger number of the lesion ['single' versus 'multiple' odds ratio (OR) 3.73, 95%CI: 1.43-9.74] in men. The OR was comparable even after adjusting for alcohol consumption, tobacco habits, age, hypertension, hypercholesterolemia, and diabetes mellitus (DM) (OR 3.88; 95% CI: 1.10-13.66). In women, there was no significant association between the ALDH2 genotypes and lacunar infarcts. The present study revealed that the ALDH2 *1/*1 genotype was significantly associated with the prevalence of multiple lacunar infarcts in Japanese men.
本研究的目的是探讨乙醛脱氢酶2（ALDH2）基因多态性与脑腔隙性梗死之间的关联。我们对两个年龄组（61岁和72岁）的居民进行了一项基于人群的横断面研究。共有376名受试者参与了该研究，其中包括脑磁共振成像和ALDH2基因的遗传分析。在61岁和72岁的受试者中，分别有46.4%和64.3%的人有一个或多个腔隙性梗死。男性梗死灶的平均数量也从2.0增加到2.8，女性从2.3增加到3.5。未发现ALDH2基因型与腔隙性梗死（≥1个）的存在之间存在显著关联。然而，在有腔隙性梗死的受试者中，ALDH2 *1/*1基因型与男性更多的病灶数量相关[“单个”与“多个”的优势比（OR）为3.73，95%可信区间：1.43 - 9.74]。即使在调整了饮酒、吸烟习惯、年龄、高血压、高胆固醇血症和糖尿病（DM）后，该OR值仍具有可比性（OR 3.88；95%可信区间：1.10 - 13.66）。在女性中，ALDH2基因型与腔隙性梗死之间无显著关联。本研究表明，ALDH2 *1/*1基因型与日本男性多发性腔隙性梗死的患病率显著相关。
