通过高渗起始阻断对水疱性口炎病毒多肽合成的差异抑制
Differential inhibition of vesicular stomatitis virus polypeptide synthesis by hypertonic initiation block.
作者信息
Nuss D L, Koch G
出版信息
J Virol. 1975 Jan;17(1):283-6. doi: 10.1128/JVI.17.1.283-286.1976.
Abstract
Synthesis of the vesicular stomatitis virus membrane matrix protein and the glycoprotein is inhibited to a greater extent than the synthesis of the nucleocapsid protein, the nonstructural protein, and the large protein when the rate of peptide chain initiation is reduced by exposure of vesicular stomatitis virus-infected cells to hypertonic medium. It is concluded that the relative sensitivity of individual viral polypeptide synthesis to hypertonic initiation block is independent of the site of synthesis, i.e., whether on membrane-associated or free polyribosomes.
摘要
当将感染水疱性口炎病毒的细胞暴露于高渗培养基中以降低肽链起始速率时，水疱性口炎病毒膜基质蛋白和糖蛋白的合成受到的抑制程度比核衣壳蛋白、非结构蛋白和大蛋白的合成更大。得出的结论是，单个病毒多肽合成对高渗起始阻断的相对敏感性与合成位点无关，即无论在膜相关多聚核糖体还是游离多聚核糖体上。
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